Ragulator binds Rag dimers

Stable Identifier
R-HSA-5653974
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, lysosomal membrane
ReviewStatus
5/5
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Ragulator binds Rag dimers
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A complex of LAMTOR1-5, known as Ragulator, interacts with Rag GTPases, recruiting them to lysosomes, an essential step in mTORC1 activation by amino acids (Sancak et al. 2010).

Literature References
PubMed ID Title Journal Year
20381137 Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Sabatini, DM, Zoncu, R, Sancak, Y, Bar-Peled, L, Nada, S, Markhard, AL

Cell 2010
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Authored
Jupe, S  (2015-02-02)
Reviewed
Zwartkruis, FJ  (2015-05-14)
Created
Jupe, S  (2014-12-03)
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