Lactose synthesis

Stable Identifier
R-HSA-5653890
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Lactose synthesis
Click the image above or here to open this pathway in the Pathway Browser
Synthesis of the disaccharide lactose takes place within the Golgi apparatus of epithelial cells of the lactating mammary gland. The synthesis itself is a single chemical reaction of free glucose and UDP-galactose to form lactose and UDP. For this reaction to occur, glucose is transported from the cytosol into the Golgi lumen, and B4GALT1 interacts with LALBA (alpha-lactalbumin) to modulate its substrate specificity (Brew and Hill 1975).
Literature References
PubMed ID Title Journal Year
806951 Lactose biosynthesis

Brew, K, Hill, RL

Rev. Physiol. Biochem. Pharmacol. 1975
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
lactose biosynthetic process (0005989)
Orthologous Events
Lactose synthesis (Bos taurus)
Lactose synthesis (Caenorhabditis elegans)
Lactose synthesis (Canis familiaris)
Lactose synthesis (Danio rerio)
Lactose synthesis (Dictyostelium discoideum)
Lactose synthesis (Drosophila melanogaster)
Lactose synthesis (Gallus gallus)
Lactose synthesis (Mus musculus)
Lactose synthesis (Plasmodium falciparum)
Lactose synthesis (Rattus norvegicus)
Lactose synthesis (Saccharomyces cerevisiae)
Lactose synthesis (Sus scrofa)
Lactose synthesis (Xenopus tropicalis)
Reviewed
Jassal, B  (2015-01-29)
Created
D'Eustachio, P  (2014-12-02)
Cite Us!