Reactome | POLD,POLE binds deISGylated PCNA after TLS

POLD,POLE binds deISGylated PCNA after TLS

Stable Identifier

R-HSA-5653838

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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POLD,POLE binds deISGylated PCNA after TLS

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Once deubiquitinated and deISGylated, PCNA can again associate with the catalytic subunit POLD1 of replicative DNA polymerase delta complex (POLD), or presumably POLE of DNA polymerase epsilon complex (POLE) (Park et al. 2014). Double monoubiquitination of PCNA-associated protein KIAA0101 (PAF15) facilitates the switch from translesion DNA synthesis (TLS) polymerases to replicative DNA polymerases POLD or POLE (Povlsen et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23000965	Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass Nielsen, ML, Poulsen, SL, Sylvestersen, KB, Beli, P, Choudhary, C, Povlsen, LK, Bekker-Jensen, S, Mailand, N, Poulsen, JW, Wagner, SA	Nat. Cell Biol.	2012
24768535	Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis Lee, SW, Seol, JH, Yang, SW, Yu, KR, Park, JM, Ka, SH, Jeon, YJ, Chung, CH	Mol. Cell	2014