Reactome | USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA

USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA

Stable Identifier

R-HSA-5653770

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA

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USP10 acts as a ubiquitin protease to remove ubiquitin from lysine K164 residue of doubly ISGylated PCNA. Deubiquitination of PCNA by USP10 causes dissociation of Y family DNA damage bypass polymerases, thus ending translesion DNA synthesis (TLS) and limiting TLS-induced mutagenesis (Park et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24768535	Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis Lee, SW, Seol, JH, Yang, SW, Yu, KR, Park, JM, Ka, SH, Jeon, YJ, Chung, CH	Mol. Cell	2014