USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA

Stable Identifier
R-HSA-5653770
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA
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USP10 acts as a ubiquitin protease to remove ubiquitin from lysine K164 residue of doubly ISGylated PCNA. Deubiquitination of PCNA by USP10 causes dissociation of Y family DNA damage bypass polymerases, thus ending translesion DNA synthesis (TLS) and limiting TLS-induced mutagenesis (Park et al. 2014).

Literature References
PubMed ID Title Journal Year
24768535 Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis

Park, JM, Yang, SW, Yu, KR, Ka, SH, Lee, SW, Seol, JH, Jeon, YJ, Chung, CH

Mol. Cell 2014
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm]
Physical Entity
USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm]
Activity
thiol-dependent ubiquitin-specific protease activity (0004843)
Orthologous Events
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Bos taurus)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Danio rerio)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)
USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-12-11)
Reviewed
Borowiec, JA  (2015-01-07)
Created
Orlic-Milacic, M  (2014-12-01)