Reactome | USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA

USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA

Stable Identifier

R-HSA-5653770

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

USP10 acts as a ubiquitin protease to remove ubiquitin from lysine K164 residue of doubly ISGylated PCNA. Deubiquitination of PCNA by USP10 causes dissociation of Y family DNA damage bypass polymerases, thus ending translesion DNA synthesis (TLS) and limiting TLS-induced mutagenesis (Park et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24768535	Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis Lee, SW, Seol, JH, Yang, SW, Yu, KR, Park, JM, Ka, SH, Jeon, YJ, Chung, CH	Mol. Cell	2014