USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA

Stable Identifier
R-HSA-5653766
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA
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Ubiquitin protease USP10 binds doubly ISGylated and monoubiquitinated PCNA (Park et al. 2014). PCNA exists as a homotrimer so that the ISGylation and monoubiquitination occur on different subunits.
Literature References
PubMed ID Title Journal Year
24768535 Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis

Lee, SW, Seol, JH, Yang, SW, Yu, KR, Park, JM, Ka, SH, Jeon, YJ, Chung, CH

Mol. Cell 2014
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Orthologous Events
USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)
USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)
USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)
USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)
USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Saccharomyces cerevisiae)
USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)
USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)
USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-12-11)
Reviewed
Borowiec, JA  (2015-01-07)
Created
Orlic-Milacic, M  (2014-12-02)
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