TRIM25 binds monoUb:164-PCNA

Stable Identifier
R-HSA-5653756
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
EFP binds monoubiquitinated PCNA
Locations in the PathwayBrowser
Summation

PCNA monoubiquitinated on lysine residue K164 (MonoUb:K164-PCNA) is bound by ISG15 E3 ligase TRIM25 (EFP) in complex with ISG15 E2 conjugating enzyme UBE2L6 (UBCH8) (Park et al. 2014).

Literature References
PubMed ID Title Journal Year
24768535 Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis

Park, JM, Yang, SW, Yu, KR, Ka, SH, Lee, SW, Seol, JH, Jeon, YJ, Chung, CH

Mol. Cell 2014
Participants
Participant Of
Orthologous Events
Authored
Reviewed