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LAMTOR2 [lysosomal membrane]
Stable Identifier
R-HSA-5653583
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
Ragulator complex protein LAMTOR2, LTOR2_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q96GS4 BORC6
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Formation of Ragulator complex (Homo sapiens)
LAMTOR2 [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2Q5 LAMTOR2
Gene Names
LAMTOR2, MAPBPIP, ROBLD3, HSPC003
Chain
chain:1-125
Reference Genes
BioGPS Gene:28956 LAMTOR2
COSMIC (genes):LAMTOR2 LAMTOR2
CTD Gene:28956 LAMTOR2
dbSNP Gene:28956 LAMTOR2
ENSEMBL:ENSG00000116586 LAMTOR2
ENSEMBL_homo_sapiens_GENE:ENSG00000116586.12 LAMTOR2
HGNC:29796 LAMTOR2
KEGG Gene (Homo sapiens):28956 LAMTOR2
Monarch:28956 LAMTOR2
NCBI Gene:28956 LAMTOR2
OMIM:610389 LAMTOR2
UCSC:Q9Y2Q5 LAMTOR2
Reference Transcript
RefSeq:NM_001145264.1 LAMTOR2
RefSeq:NM_014017.3 LAMTOR2
Other Identifiers
11717016_a_at
11757690_a_at
16671889
218291_PM_at
218291_at
2361243
2361244
2361245
2361247
2361248
2361251
2361253
2361254
2361255
2361256
28956
45731_at
7906072
A_23_P103698
A_24_P182433
A_33_P3246068
GE58544
GO:0001558
GO:0005085
GO:0005515
GO:0005764
GO:0005765
GO:0005768
GO:0005770
GO:0005773
GO:0005886
GO:0008104
GO:0010008
GO:0010761
GO:0016020
GO:0023052
GO:0031410
GO:0031902
GO:0032008
GO:0034330
GO:0035579
GO:0038202
GO:0043226
GO:0043410
GO:0048870
GO:0060090
GO:0070821
GO:0071230
GO:0071986
GO:0098772
GO:0150116
GO:1902414
GO:1904263
GO:1990877
HMNXSV003010810
ILMN_1756352
PH_hs_0017001
PH_hs_0032796
TC01001310.hg
g7661727_3p_s_at
Participates
as an input of
Formation of Ragulator complex (Homo sapiens)
as a component of
Ragulator [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
LAMTOR2 [specific granule membrane]
LAMTOR2 [plasma membrane]
LAMTOR2 [tertiary granule membrane]
LAMTOR2 [endosome membrane]
Inferred To
LAMTOR2 [lysosomal membrane]
(Bos taurus)
LAMTOR2 [lysosomal membrane]
(Canis familiaris)
LAMTOR2 [lysosomal membrane]
(Gallus gallus)
LAMTOR2 [lysosomal membrane]
(Schizosaccharomyces pombe)
LAMTOR2 [lysosomal membrane]
(Sus scrofa)
ENSRNOG00000066475 [lysosomal membrane]
(Rattus norvegicus)
lmtr-2 [lysosomal membrane]
(Caenorhabditis elegans)
lamtor2 [lysosomal membrane]
(Danio rerio)
lamtor2 [lysosomal membrane]
(Xenopus tropicalis)
Lamtor2 [lysosomal membrane]
(Drosophila melanogaster)
Lamtor2 [lysosomal membrane]
(Mus musculus)
Ghost homologue of LAMTOR2 [lysosomal membrane]
(Saccharomyces cerevisiae)
mapbpip [lysosomal membrane]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_054736.1
,
NP_001138736.1
OpenTargets
ENSG00000116586
GeneCards
Q9Y2Q5
HPA
ENSG00000116586-LAMTOR2
Ensembl
ENSP00000357288
,
ENSP00000357287
,
ENST00000368302
,
ENSG00000116586
,
ENST00000368305
,
ENST00000368304
,
ENSP00000357285
PRO
Q9Y2Q5
Pharos - Targets
Q9Y2Q5
Orphanet
17582
PDB
5Y3A
,
7UX2
,
5YK3
,
6B9X
,
7UXH
,
6NZD
,
6WJ2
,
7T3B
,
6EHR
,
7T3A
,
5X6V
,
5X6U
,
6WJ3
,
6EHP
,
5Y39
,
6ULG
,
8DHB
,
7UXC
,
7T3C
,
6U62
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHA4 LAMTOR3
5
LAMTOR3 [specific granule membrane]
(R-HSA-6800178)
LAMTOR3 [plasma membrane]
(R-HSA-6806307)
LAMTOR3 [tertiary granule membrane]
(R-HSA-6800189)
LAMTOR3 [endosome membrane]
(R-HSA-5693294)
LAMTOR3 [lysosomal membrane]
(R-HSA-5653581)
0.961
40
UniProt:Q6IAA8 LAMTOR1
5
LAMTOR1 [specific granule membrane]
(R-HSA-6799631)
LAMTOR1 [lysosomal membrane]
(R-HSA-5653582)
LAMTOR1 [azurophil granule membrane]
(R-HSA-6799633)
LAMTOR1 [plasma membrane]
(R-HSA-6806270)
LAMTOR1 [ficolin-1-rich granule membrane]
(R-HSA-6801003)
0.937
25
UniProt:Q9HB90 RRAGC
1
RRAGC [cytosol]
(R-HSA-5653949)
0.812
13
UniProt:O43504 LAMTOR5
1
LAMTOR5 [lysosomal membrane]
(R-HSA-5655441)
0.812
10
UniProt:Q7L523 RRAGA
2
K63polyUb-K142,K220,K230,K244-RRAGA [cytosol]
(R-HSA-8938830)
RRAGA [cytosol]
(R-HSA-5653577)
0.788
9
UniProt:Q0VGL1 LAMTOR4
1
LAMTOR4 [lysosomal membrane]
(R-HSA-5655432)
0.758
9
UniProt:Q96GS4 BORC6
0.742
7
UniProt:Q5VZM2 RRAGB
1
RRAGB [cytosol]
(R-HSA-5653579)
0.725
8
UniProt:Q8NBW4 SLC38A9
1
SLC38A9 [lysosomal membrane]
(R-HSA-5215938)
0.669
5
UniProt:Q5VZM2-2 RRAGB
0.558
3
UniProt:P11279 LAMP1
3
LAMP1 [ficolin-1-rich granule membrane]
(R-HSA-6800966)
LAMP1 [plasma membrane]
(R-HSA-6806268)
LAMP1 [azurophil granule membrane]
(R-HSA-6799162)
0.527
3
UniProt:Q9NQL2 RRAGD
1
RRAGD [cytosol]
(R-HSA-5653953)
0.527
5
UniProt:P61421 ATPV0D1
3
ATP6V0D1 [endosome membrane]
(R-HSA-912592)
ATP6V0D1 [phagocytic vesicle membrane]
(R-HSA-1222571)
ATP6V0D1 [lysosomal membrane]
(R-HSA-9640177)
0.527
2
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