Reactome | LAMTOR1 [lysosomal membrane]

LAMTOR1 [lysosomal membrane]

Stable Identifier

R-HSA-5653582

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

Ragulator complex protein LAMTOR1, LTOR1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q96GS4 BORC6

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External Reference Information

External Reference

UniProt:Q6IAA8 LAMTOR1

Gene Names

LAMTOR1, C11orf59, PDRO, PP7157

Chain

initiator methionine:, chain:2-161

Reference Genes

BioGPS Gene:55004 LAMTOR1

COSMIC (genes):LAMTOR1 LAMTOR1

CTD Gene:55004 LAMTOR1

dbSNP Gene:55004 LAMTOR1

ENSEMBL:ENSG00000149357 LAMTOR1

ENSEMBL_homo_sapiens_GENE:ENSG00000149357.10 LAMTOR1

HGNC:26068 LAMTOR1

KEGG Gene (Homo sapiens):55004 LAMTOR1

Monarch:55004 LAMTOR1

NCBI Gene:55004 LAMTOR1

OMIM:613510 LAMTOR1

UCSC:Q6IAA8 LAMTOR1

Reference Transcript

RefSeq:NM_017907.2 LAMTOR1

Other Identifiers

11742925_a_at

11749390_x_at

11756743_x_at

223009_PM_at

223009_at

3380988

3380989

3380991

3380992

3380993

3380994

3380995

55004

56435_at

7950119

A_23_P2114

GE82246

GO:0001558

GO:0001919

GO:0005085

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005886

GO:0007032

GO:0007040

GO:0008104

GO:0010874

GO:0016020

GO:0016192

GO:0016197

GO:0023052

GO:0031410

GO:0031669

GO:0031902

GO:0032008

GO:0032418

GO:0035577

GO:0035579

GO:0038202

GO:0042632

GO:0043226

GO:0043410

GO:0043495

GO:0045121

GO:0051020

GO:0060090

GO:0060620

GO:0070062

GO:0071230

GO:0071986

GO:0072657

GO:0098772

GO:0101003

GO:0150032

GO:1904263

GO:1990877

HMNXSV003050438

ILMN_1815878

PH_hs_0025135

PH_hs_0035941

TC11002053.hg

g12804574_3p_at

Participates

as an input of

Formation of Ragulator complex (Homo sapiens)

as a component of

Ragulator [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

LAMTOR1 [specific granule membrane]

LAMTOR1 [azurophil granule membrane]

LAMTOR1 [plasma membrane]

LAMTOR1 [ficolin-1-rich granule membrane]

Inferred To

Lamtor1 [lysosomal membrane] (Drosophila melanogaster)

Lamtor1 [lysosomal membrane] (Mus musculus)

Lamtor1 [lysosomal membrane] (Rattus norvegicus)

lamtor1 [lysosomal membrane] (Xenopus tropicalis)

Ghost homologue of LAMTOR1 [lysosomal membrane] (Caenorhabditis elegans)

Ghost homologue of LAMTOR1 [lysosomal membrane] (Danio rerio)

Ghost homologue of LAMTOR1 [lysosomal membrane] (Saccharomyces cerevisiae)

Ghost homologue of LAMTOR1 [lysosomal membrane] (Schizosaccharomyces pombe)

LAMTOR1 [lysosomal membrane] (Bos taurus)

LAMTOR1 [lysosomal membrane] (Canis familiaris)

LAMTOR1 [lysosomal membrane] (Dictyostelium discoideum)

LAMTOR1 [lysosomal membrane] (Gallus gallus)

LAMTOR1 [lysosomal membrane] (Sus scrofa)

Cross References

RefSeq

NP_060377.1

OpenTargets

ENSG00000149357

GeneCards

Q6IAA8

HPA

ENSG00000149357-LAMTOR1

Ensembl

ENSP00000278671, ENST00000278671, ENSG00000149357

PRO

Q6IAA8

Pharos - Targets

Q6IAA8

PDB

5Y39, 6ULG, 6U62, 6NZD, 6WJ3, 6WJ2, 7UXH, 7T3C, 6B9X, 5X6V, 5Y3A, 6EHR, 5X6U, 5YK3, 8DHB, 7UX2, 7T3B, 7UXC, 7T3A, 6EHP

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y2Q5 LAMTOR2	5	LAMTOR2 [specific granule membrane] (R-HSA-6800168) LAMTOR2 [plasma membrane] (R-HSA-6806286) LAMTOR2 [tertiary granule membrane] (R-HSA-6800165) LAMTOR2 [endosome membrane] (R-HSA-5693293) LAMTOR2 [lysosomal membrane] (R-HSA-5653583)	0.937	25
UniProt:Q9HB90 RRAGC	1	RRAGC [cytosol] (R-HSA-5653949)	0.913	22
UniProt:Q0VGL1 LAMTOR4	1	LAMTOR4 [lysosomal membrane] (R-HSA-5655432)	0.876	14
UniProt:Q9UHA4 LAMTOR3	5	LAMTOR3 [specific granule membrane] (R-HSA-6800178) LAMTOR3 [plasma membrane] (R-HSA-6806307) LAMTOR3 [tertiary granule membrane] (R-HSA-6800189) LAMTOR3 [endosome membrane] (R-HSA-5693294) LAMTOR3 [lysosomal membrane] (R-HSA-5653581)	0.861	17
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.826	12
UniProt:Q7L523 RRAGA	2	K63polyUb-K142,K220,K230,K244-RRAGA [cytosol] (R-HSA-8938830) RRAGA [cytosol] (R-HSA-5653577)	0.81	15
UniProt:Q5VZM2 RRAGB	1	RRAGB [cytosol] (R-HSA-5653579)	0.788	8
UniProt:Q8NBW4 SLC38A9	1	SLC38A9 [lysosomal membrane] (R-HSA-5215938)	0.767	15
UniProt:Q9NQL2 RRAGD	1	RRAGD [cytosol] (R-HSA-5653953)	0.725	6
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P61086 UBE2K	2	UBE2K [cytosol] (R-HSA-934631) Ub-C92-UBE2K [cytosol] (R-HSA-8864200)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:P78358 CTG1B			0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [platelet alpha granule membrane] (R-HSA-61489) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772)	0.556	3
UniProt:P20339 RAB5A	7	GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [cytosol] (R-HSA-8870432) RAB5A [early endosome membrane] (R-HSA-2130175) RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:Q8N122 RPTOR	3	RPTOR [nucleoplasm] (R-HSA-5083664) RPTOR [cytosol] (R-HSA-3006727) p-S722,S792-RPTOR [cytosol] (R-HSA-3132767)	0.527	2
UniProt:Q96GS4 BORC6			0.527	5
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [specific granule membrane] (R-HSA-6799631) LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003)	0.471	2

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