Reactome | LAMTOR3 [lysosomal membrane]

LAMTOR3 [lysosomal membrane]

Stable Identifier

R-HSA-5653581

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

Ragulator complex protein LAMTOR3, LTOR3_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q96GS4 BORC6

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External Reference Information

External Reference

UniProt:Q9UHA4 LAMTOR3

Gene Names

LAMTOR3, MAP2K1IP1, MAPKSP1, PRO2783

Chain

chain:1-124

Reference Genes

BioGPS Gene:8649 LAMTOR3

COSMIC (genes):LAMTOR3 LAMTOR3

CTD Gene:8649 LAMTOR3

dbSNP Gene:8649 LAMTOR3

ENSEMBL:ENSG00000109270 LAMTOR3

ENSEMBL_homo_sapiens_GENE:ENSG00000109270.13 LAMTOR3

HGNC:15606 LAMTOR3

KEGG Gene (Homo sapiens):8649 LAMTOR3

Monarch:8649 LAMTOR3

NCBI Gene:8649 LAMTOR3

OMIM:603296 LAMTOR3

UCSC:Q9UHA4 LAMTOR3

Reference Transcript

Other Identifiers

11718768_a_at

11718769_a_at

16978301

217971_PM_at

217971_at

227562_PM_at

227562_at

2779398

2779399

2779400

2779409

2779410

2779411

2779412

2779413

2779414

2779415

2779418

2779421

2779423

2779424

2779425

2779427

2872528

46103_at

46221_i_at

46222_r_at

8101925

8649

A_23_P110362

A_32_P10311

A_33_P3251480

GE80264

GE87054

GO:0005085

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005886

GO:0005925

GO:0008104

GO:0010008

GO:0016020

GO:0019209

GO:0023052

GO:0031410

GO:0031902

GO:0032006

GO:0032008

GO:0035579

GO:0038202

GO:0043226

GO:0043410

GO:0060090

GO:0070062

GO:0070821

GO:0071230

GO:0071986

GO:0098772

GO:1902414

GO:1904263

GO:1990877

HMNXSV003011044

Hs.332556.0.S1_3p_at

ILMN_1659415

PH_hs_0030174

PH_hs_0037100

TC04001416.hg

TC04002643.hg

g11496276_3p_at

Participates

as an input of

Formation of Ragulator complex (Homo sapiens)

as a component of

Ragulator [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

LAMTOR3 [specific granule membrane]

LAMTOR3 [plasma membrane]

LAMTOR3 [tertiary granule membrane]

LAMTOR3 [endosome membrane]

Inferred To

Ghost homologue of LAMTOR3 [lysosomal membrane] (Saccharomyces cerevisiae)

Ghost homologue of LAMTOR3 [lysosomal membrane] (Schizosaccharomyces pombe)

Lamtor3 [lysosomal membrane] (Drosophila melanogaster)

Lamtor3 [lysosomal membrane] (Mus musculus)

Lamtor3 [lysosomal membrane] (Rattus norvegicus)

LAMTOR3 [lysosomal membrane] (Bos taurus)

LAMTOR3 [lysosomal membrane] (Canis familiaris)

LAMTOR3 [lysosomal membrane] (Dictyostelium discoideum)

LAMTOR3 [lysosomal membrane] (Gallus gallus)

LAMTOR3 [lysosomal membrane] (Sus scrofa)

lamtor3 [lysosomal membrane] (Danio rerio)

lamtor3 [lysosomal membrane] (Xenopus tropicalis)

lmtr-3 [lysosomal membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_068805.1, NP_001230665.1

OpenTargets

ENSG00000109270

HPA

ENSG00000109270-LAMTOR3

GeneCards

Q9UHA4

Ensembl

ENST00000499666, ENSP00000226522, ENST00000226522, ENSP00000424183, ENSG00000109270

PRO

Q9UHA4

Pharos - Targets

Q9UHA4

PDB

7T3B, 6EHP, 6ULG, 7UX2, 6NZD, 7UXH, 8DHB, 5Y39, 1SKO, 7T3A, 5X6V, 6WJ3, 6U62, 3CPT, 7UXC, 5Y3A, 6EHR, 2ZL1, 6WJ2, 6B9X, 7T3C, 5X6U, 5YK3

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y2Q5 LAMTOR2	5	LAMTOR2 [specific granule membrane] (R-HSA-6800168) LAMTOR2 [plasma membrane] (R-HSA-6806286) LAMTOR2 [tertiary granule membrane] (R-HSA-6800165) LAMTOR2 [endosome membrane] (R-HSA-5693293) LAMTOR2 [lysosomal membrane] (R-HSA-5653583)	0.961	40
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [specific granule membrane] (R-HSA-6799631) LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003)	0.861	17
UniProt:Q9HB90 RRAGC	1	RRAGC [cytosol] (R-HSA-5653949)	0.725	7
UniProt:Q5VZM2 RRAGB	1	RRAGB [cytosol] (R-HSA-5653579)	0.725	7
UniProt:Q9NQL2 RRAGD	1	RRAGD [cytosol] (R-HSA-5653953)	0.643	4
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.643	5
UniProt:Q0VGL1 LAMTOR4	1	LAMTOR4 [lysosomal membrane] (R-HSA-5655432)	0.643	5
UniProt:Q8NBW4 SLC38A9	1	SLC38A9 [lysosomal membrane] (R-HSA-5215938)	0.623	7
UniProt:Q9BWW8 APOL6			0.556	3
UniProt:P19532 TFE3	1	TFE3 [nucleoplasm] (R-HSA-9857366)	0.556	3
UniProt:Q9GZT8 NIF3L			0.556	3
UniProt:Q96PF1 TGM7			0.556	3
UniProt:Q8NAM6 ZSCAN4	1	ZSCAN4 [nucleoplasm] (R-HSA-9816447)	0.556	3
UniProt:Q8N122 RPTOR	3	RPTOR [nucleoplasm] (R-HSA-5083664) RPTOR [cytosol] (R-HSA-3006727) p-S722,S792-RPTOR [cytosol] (R-HSA-3132767)	0.527	3
UniProt:Q7L523 RRAGA	2	K63polyUb-K142,K220,K230,K244-RRAGA [cytosol] (R-HSA-8938830) RRAGA [cytosol] (R-HSA-5653577)	0.527	7
UniProt:Q96GS4 BORC6			0.527	4

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