Fructose biosynthesis

Stable Identifier
R-HSA-5652227
Type
Pathway
Species
Homo sapiens
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The conversion of glucose to fructose via sorbitol was demonstrated by Hers (1960) in the seminal vesicles of sheep, has since been demonstrated as well in human epidydimal tissue (Frenette et al. 2006), and appears to be the physiological source of the abundant fructose found in seminal fluid. The enzymes of the pathway are likewise abundant in the eye lens and in neurons, where their physiological role is less clear but where they appear to play a central role in diabetic tissue damage (Oates 2008).

Literature References
PubMed ID Title Journal Year
14401391 [The mechanism of the formation of seminal fructose and fetal fructose]

Hers, HG

Biochim. Biophys. Acta 1960
18220710 Aldose reductase, still a compelling target for diabetic neuropathy

Oates, PJ

Curr Drug Targets 2008
16278369 Polyol pathway in human epididymis and semen

Frenette, G, Thabet, M, Sullivan, R

J. Androl. 2006
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