Reactome | SORD oxidizes D-sorbitol to Fru

SORD oxidizes D-sorbitol to Fru

Stable Identifier

R-HSA-5652195

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

D-sorbitol + NAD(+) => H(+) + keto-D-fructose + NADH, sorbitol + NAD+ => fructose + NADH + H+

ReviewStatus

5/5

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Cytosolic SORD (sorbitol dehydrogenase) catalyzes the reaction of D-sorbitol and NAD+ to form fructose (Fru) and NADH + H+. This reaction was first described by Hers (1960) in sheep seminal vesicles; the human enzyme was identified by O'Brien et al. (1983). The active enzyme is a tetramer with four associated Zn2+ ions (Pauly et al. 2003) whose amino-terminal methionine residue has been removed (Karlsson et al. 1989).

Literature References

PubMed ID	Title	Journal	Year
12962626	X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase Adams, PD, Cunningham, D, Kamath, A, Mcguire, D, Chrunyk, B, Madura, R, Lee, SE, Griffor, M, Pauly, TA, Beebe, DA, Ekstrom, JL, Wasilko, D, Subashi, T, Rath, VL, Oates, PJ, Mylari, BL, Watts, P	Structure	2003
6870831	Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase Edwards, MR, Schofield, PJ, O'Brien, MM	Biochem. J.	1983
2691249	Variability within mammalian sorbitol dehydrogenases. The primary structure of the human liver enzyme Höög, JO, Karlsson, C, Jörnvall, H, Maret, W, Auld, DS	Eur. J. Biochem.	1989
14401391	[The mechanism of the formation of seminal fructose and fetal fructose] Hers, HG	Biochim. Biophys. Acta	1960