SORD oxidizes D-sorbitol to Fru

Stable Identifier
R-HSA-5652195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
sorbitol + NAD+ => fructose + NADH + H+
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Cytosolic SORD (sorbitol dehydrogenase) catalyzes the reaction of D-sorbitol and NAD+ to form fructose (Fru) and NADH + H+. This reaction was first described by Hers (1960) in sheep seminal vesicles; the human enzyme was identified by O'Brien et al. (1983). The active enzyme is a tetramer with four associated Zn2+ ions (Pauly et al. 2003) whose amino-terminal methionine residue has been removed (Karlsson et al. 1989).

Literature References
PubMed ID Title Journal Year
6870831 Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase

O'Brien, MM, Schofield, PJ, Edwards, MR

Biochem. J. 1983
12962626 X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase

Pauly, TA, Ekstrom, JL, Beebe, DA, Chrunyk, B, Cunningham, D, Griffor, M, Kamath, A, Lee, SE, Madura, R, Mcguire, D, Subashi, T, Wasilko, D, Watts, P, Mylari, BL, Oates, PJ, Adams, PD, Rath, VL

Structure 2003
2691249 Variability within mammalian sorbitol dehydrogenases. The primary structure of the human liver enzyme

Karlsson, C, Maret, W, Auld, DS, Höög, JO, Jörnvall, H

Eur. J. Biochem. 1989
14401391 [The mechanism of the formation of seminal fructose and fetal fructose]

Hers, HG

Biochim. Biophys. Acta 1960
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
L-iditol 2-dehydrogenase activity of SORD tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created