SORD oxidizes D-sorbitol to Fru

Stable Identifier
Reaction [transition]
Homo sapiens
D-sorbitol + NAD(+) => H(+) + keto-D-fructose + NADH, sorbitol + NAD+ => fructose + NADH + H+
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic SORD (sorbitol dehydrogenase) catalyzes the reaction of D-sorbitol and NAD+ to form fructose (Fru) and NADH + H+. This reaction was first described by Hers (1960) in sheep seminal vesicles; the human enzyme was identified by O'Brien et al. (1983). The active enzyme is a tetramer with four associated Zn2+ ions (Pauly et al. 2003) whose amino-terminal methionine residue has been removed (Karlsson et al. 1989).

Literature References
PubMed ID Title Journal Year
12962626 X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase

Adams, PD, Cunningham, D, Kamath, A, Mcguire, D, Chrunyk, B, Madura, R, Lee, SE, Griffor, M, Pauly, TA, Beebe, DA, Ekstrom, JL, Wasilko, D, Subashi, T, Rath, VL, Oates, PJ, Mylari, BL, Watts, P

Structure 2003
6870831 Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase

Edwards, MR, Schofield, PJ, O'Brien, MM

Biochem. J. 1983
2691249 Variability within mammalian sorbitol dehydrogenases. The primary structure of the human liver enzyme

Höög, JO, Karlsson, C, Jörnvall, H, Maret, W, Auld, DS

Eur. J. Biochem. 1989
14401391 [The mechanism of the formation of seminal fructose and fetal fructose]

Hers, HG

Biochim. Biophys. Acta 1960
Catalyst Activity

L-iditol 2-dehydrogenase activity of SORD tetramer [cytosol]

Orthologous Events
Cite Us!