Reactome | AKR1B1 reduces Glc to D-sorbitol

AKR1B1 reduces Glc to D-sorbitol

Stable Identifier

R-HSA-5652172

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

glucose + NADPH + H+ => sorbitol + NADP+

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Cytosolic AKR1B1 (aldose reductase) catalyzes the reaction of glucose (Glc) and NADPH + H+ to form D-sorbitol and NADP+. This reaction was first described by Hers (1960) in sheep seminal vesicles; the human enzyme was identified by Nishimura et al. (1990) and is a potential target for treatment of diabetic neuropathy (Oates, 2008). The active enzyme is a monomer (Ruiz et al. 2004) whose amino-terminal methionine residue has been removed (Jacquinod et al. 1993). Under physiological conditions, formation of D-sorbitol is strongly favored (Grimshaw 1992).

Literature References

PubMed ID	Title	Journal	Year
14401390	[Aldose reductase] Hers, HG	Biochim. Biophys. Acta	1960
8281941	Sequence of pig lens aldose reductase and electrospray mass spectrometry of non-covalent and covalent complexes Jaquinod, M, Potier, N, Klarskov, K, Reymann, JM, Sorokine, O, Kieffer, S, Barth, P, Andriantomanga, V, Biellmann, JF, Van Dorsselaer, A	Eur. J. Biochem.	1993
1420136	Aldose reductase: model for a new paradigm of enzymic perfection in detoxification catalysts Grimshaw, CE	Biochemistry	1992
18220710	Aldose reductase, still a compelling target for diabetic neuropathy Oates, PJ	Curr Drug Targets	2008
2112546	Cloning and expression of human aldose reductase Nishimura, C, Matsuura, Y, Kokai, Y, Akera, T, Carper, D, Morjana, N, Lyons, C, Flynn, TG	J. Biol. Chem.	1990
15272156	The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48 Ruiz, F, Hazemann, I, Mitschler, A, Joachimiak, A, Schneider, T, Karplus, M, Podjarny, A	Acta Crystallogr. D Biol. Crystallogr.	2004