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Damaged dsDNA becomes damaged DNA template
Stable Identifier
R-HSA-5652137
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
Damaged dsDNA becomes damaged DNA template (Homo sapiens)
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If a damaged double strand DNA (dsDNA) is not repaired prior to the next round of DNA replication, it provides a damaged (lesioned) DNA template that triggers mutagenic (erroneous) incorporation of nucleotides in the newly synthesized DNA strand through the process of DNA damage bypass (Friedberg et al. 2001).
Literature References
PubMed ID
Title
Journal
Year
11595180
Error-prone DNA polymerases: novel structures and the benefits of infidelity.
Kisker, C
,
Friedberg, EC
,
Fischhaber, PL
Cell
2001
Participants
Input
Damaged dsDNA [nucleoplasm]
(Homo sapiens)
Output
Damaged DNA Template [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
Authored
Orlic-Milacic, M (2014-12-11)
Reviewed
Borowiec, JA (2015-01-07)
Created
Orlic-Milacic, M (2014-11-28)
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