Fructose metabolism

Stable Identifier
Homo sapiens
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Fructose is found in fruits, is one of the components of the disaccharide sucrose, and is a widely used sweetener in processed foods. Dietary fructose is catabolized in the liver via fructose 1-phosphate to yield dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, which then are converted to pyruvate via steps of canonical glycolysis (Hers & Kusaka 1953; Sillero et al. 1969). Excessive dietary intake of fructose and its metabolism have been associated with major disease risks in humans, although this issue remains controversial (Kolderup & Svihus 2015; DiNicolantonio et al. 2015; Bray 2013; Mayes 1993; Rippe & Angelopoulos 2013; van Buul et al. 2013). Fructose can also be synthesized from glucose via the polyol pathway (Hers 1960; Oates 2008). This synthetic process provides the fructose found in seminal fluid and, in other tissues, can contribute to pathologies of diabetes.
Literature References
PubMed ID Title Journal Year
23493540 Sucrose, high-fructose corn syrup, and fructose, their metabolism and potential health effects: what do we really know?

Rippe, JM, Angelopoulos, TJ

Adv Nutr 2013
23493538 Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people

Bray, GA

Adv Nutr 2013
26199742 Fructose Metabolism and Relation to Atherosclerosis, Type 2 Diabetes, and Obesity

Svihus, B, Kolderup, A

J Nutr Metab 2015
24666553 Misconceptions about fructose-containing sugars and their role in the obesity epidemic

Brouns, FJ, Tappy, L, van Buul, VJ

Nutr Res Rev 2014
13093749 [The metabolism of fructose-1-phosphate in the liver.]

Hers, HG, Kusaka, T

Biochim Biophys Acta 1953
18220710 Aldose reductase, still a compelling target for diabetic neuropathy

Oates, PJ

Curr Drug Targets 2008
8213607 Intermediary metabolism of fructose

Mayes, PA

Am. J. Clin. Nutr. 1993
14401391 [The mechanism of the formation of seminal fructose and fetal fructose]

Hers, HG

Biochim. Biophys. Acta 1960
25639270 Added fructose: a principal driver of type 2 diabetes mellitus and its consequences

DiNicolantonio, JJ, O'Keefe, JH, Lucan, SC

Mayo Clin. Proc. 2015
5823111 Enzymes involved in fructose metabolism in liver and the glyceraldehyde metabolic crossroads

Sillero, MA, Sillero, A, Sols, A

Eur. J. Biochem. 1969
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