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PARG [nucleoplasm]
Stable Identifier
R-HSA-5651826
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Poly(ADP-ribose) glycohydrolase
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)
PARG dePARylates PARP1,PARP2 (Homo sapiens)
PARG [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Homo sapiens)
PARG [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86W56 PARG
Gene Names
PARG
Chain
chain:1-976
Reference Genes
BioGPS Gene:670 BPHL
BioGPS Gene:8505 PARG
COSMIC (genes):PARG PARG
CTD Gene:670 BPHL
CTD Gene:8505 PARG
dbSNP Gene:670 BPHL
dbSNP Gene:8505 PARG
ENSEMBL:ENSG00000227345 PARG
HGNC:8605 PARG
KEGG:hsa:8505 PARG
Monarch:670 BPHL
Monarch:8505 PARG
NCBI Gene:670 BPHL
NCBI Gene:8505 PARG
OMIM:603501 PARG
UCSC:Q86W56 PARG
Reference Transcript
RefSeq:NM_003631.3 PARG
RefSeq:NM_001324381.1 PARG
RefSeq:NM_001303487.1 PARG
RefSeq:NM_001303486.1 PARG
RefSeq:NM_001302777.1 BPHL
Other Identifiers
11741005_a_at
11741006_s_at
11741007_s_at
11746357_s_at
11747968_s_at
11749372_s_at
11758350_s_at
16704894
16713674
16714200
205060_PM_at
205060_at
2564551
3207381
3246318
3246319
3246320
3246326
3246327
3246328
3246329
3246330
3246332
3246333
3246334
3246335
3246338
3246339
3246340
3246341
3287072
3287073
3287075
3287077
3287082
3287083
3288846
3288847
3288848
3288849
3288850
3288851
3288852
3288853
3288856
3288857
3288860
3288862
3288864
3288865
3288866
3288867
3288870
3288871
3288872
3288879
3288880
3288881
3288915
3288916
3288917
3288921
3288923
3288924
3288925
3288926
3288927
3288932
3288933
3288934
3288989
3288995
3288997
337_at
38270_at
75836_s_at
7933561
8505
AF005043_at
GE58307
GO:0003824
GO:0004649
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0005975
GO:0006282
GO:0006287
GO:0006974
GO:0009225
GO:0016604
GO:0016787
GO:0043226
GO:0055086
GO:1901135
GO:1990966
HMNXSV003018480
HMNXSV003045590
ILMN_1694752
ILMN_1800786
ILMN_2410428
PH_hs_0005077
TC10000339.hg
TC10002637.hg
g4505608_3p_at
g4505608_3p_x_at
This entity regulates
Positively
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site
(Homo sapiens)
Inferred To
PARG [nucleoplasm]
(Bos taurus)
PARG [nucleoplasm]
(Dictyostelium discoideum)
PARG [nucleoplasm]
(Gallus gallus)
PARG [nucleoplasm]
(Mus musculus)
PARG [nucleoplasm]
(Rattus norvegicus)
PARG [nucleoplasm]
(Sus scrofa)
PARG [nucleoplasm]
(Xenopus tropicalis)
Parg [nucleoplasm]
(Drosophila melanogaster)
Cross References
OpenTargets
ENSG00000227345
ENSEMBL
ENSP00000384408
,
ENST00000616448
,
ENSG00000227345
,
ENST00000402038
,
ENSP00000484285
HPA
ENSG00000227345-PARG
GeneCards
PARG
ZINC - Substances
PARG_HUMAN
ZINC target
Q86W56
PRO
Q86W56
Pharos - Targets
Q86W56
GlyGen
Q86W56
ZINC - Predictions - Purchasable
PARG_HUMAN
HMDB Protein
HMDBP10629
PDB
6O9Y
,
6O9X
,
4A0D
,
6OA1
,
6OA0
,
5A7R
,
6HML
,
6OA3
,
6HMK
,
5LHB
,
6HMN
,
6HMM
,
6HH6
,
4B1G
,
7KG6
,
6OAK
,
4B1H
,
7KG7
,
7KFP
,
7KG1
,
7KG0
,
6OAL
,
7KG8
,
4B1I
,
4B1J
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