Reactome | LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA

LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA

Stable Identifier

R-HSA-5651809

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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General

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LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA

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After the PCNA-dependent long patch base excision (BER) is completed, PCNA, APEX1 and LIG1 dissociate from repaired DNA (Klungland and Lindahl 1997, Ranalli et al. 2002a, Ranalli et al. 2002b).

Literature References

PubMed ID	Title	Journal	Year
12200445	AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair. Ranalli, TA, Tom, S, Bambara, RA	J Biol Chem	2002
11698410	Mechanism underlying replication protein a stimulation of DNA ligase I Ranalli, TA, DeMott, MS, Bambara, RA	J. Biol. Chem.	2002
9214649	Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). Klungland, A, Lindahl, T	EMBO J	1997

Participants

Input

LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)

Output

Participant Of

hasEvent

PCNA-Dependent Long Patch Base Excision Repair

Authored

Orlic-Milacic, M (2014-12-03)

Reviewed

Borowiec, JA (2014-12-22)

Created

Orlic-Milacic, M (2014-11-24)