Oxidative damage to the AP site

Stable Identifier
R-HSA-5649856
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The APEX1-bound AP (apurinic/apyrimidinic) 5'-deoxyribose phosphate at the single strand break (SSB) is susceptible to oxidative damage, and can be converted to tetrahydrofuran-like 1,2-dideoxyribose phosphate during base excision repair (BER) (Matsumoto et al. 1994, Klungland and Lindahl 1997).

Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!