Reactome | WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)

WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)

Stable Identifier

R-HSA-5649802

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

WHSC1L1 (KMT3F) methylates Me2K28-histone H3 (H3K27), WHSC1L1 methylates Me2K28-histone H3

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

WHSC1 (MMSET, KMT3G) is able to mono-, di- and trimethylate lysine-28 (Kim et al. 2008). WHSC1L1 (KMT3F, WHISTLE) can di- and tri-methylate lysine-28 of histone H3 (H3K27) if it has been previously methylated at this residue (Kim et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
18172012	Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity Kee, HJ, Baek, HJ, Choe, NW, Kim, SM, Kim, JY, Kook, H, Kook, H, Eom, GH, Seo, SB	Mol. Cell. Biol.	2008
16682010	Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity Kee, HJ, Kim, SK, Kim, SM, Choe, NW, Kook, H, Kim, YS, Eom, GH, Kook, H, Kim, JY, Seo, SB	Biochem. Biophys. Res. Commun.	2006