DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)

Stable Identifier
R-HSA-5649799
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
DOT1L (KMT4) methylates Me2K80-histone H3 (H3K79), DOT1L methylates dimethyl-lysine-80 of histone H3
Locations in the PathwayBrowser
Summation

DOT1L is responsible for the mono-, di-, and trimethylation of histone H3 in a nonprocessive manner (Min et al. 2003, Frederiks et al. 2008). It appear to be solely responsible for H3K79 methylation, since knockout of Dot1 in yeast, flies and mice results in complete loss of H3K79 methylation (van Leeuwen et al. 2002, Shanower et al. 2005, Jones et al. 2008).

Literature References
PubMed ID Title Journal Year
12123582 Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

Feng, Q, Wang, H, Ng, HH, Erdjument-Bromage, H, Tempst, P, Struhl, K, Zhang, Y

Curr. Biol. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone-lysine N-methyltransferase activity of DOT1L [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed