Reactome | DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)

DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)

Stable Identifier

R-HSA-5649799

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DOT1L (KMT4) methylates Me2K80-histone H3 (H3K79), DOT1L methylates dimethyl-lysine-80 of histone H3

ReviewStatus

5/5

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DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)

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DOT1L is responsible for the mono-, di-, and trimethylation of histone H3 in a nonprocessive manner (Min et al. 2003, Frederiks et al. 2008). It appear to be solely responsible for H3K79 methylation, since knockout of Dot1 in yeast, flies and mice results in complete loss of H3K79 methylation (van Leeuwen et al. 2002, Shanower et al. 2005, Jones et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
12123582	Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain Ng, HH, Zhang, Y, Wang, H, Feng, Q, Struhl, K, Tempst, P, Erdjument-Bromage, H	Curr. Biol.	2002