Reactome | NEIL1,NEIL2 incises DNA strand 5' to the AP site

NEIL1,NEIL2 incises DNA strand 5' to the AP site

Stable Identifier

R-HSA-5649711

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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NEIL1,NEIL2 incises DNA strand 5' to the AP site

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NEIL1 or NEIL2 bound to AP-dsDNA (DNA with apurinic/apyrimidinic site) act as beta/delta lyases to cleave the AP-site containing DNA strand 5' to the AP site, thus producing DNA strand with a terminal 3' phosphate (3'Pi) and a DNA strand with a terminal 5'-deoxyribosephosphate (5'dRP) (Wiederhold et al. 2004, Das et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16982218	NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells Das, A, Wiederhold, L, Leppard, JB, Kedar, P, Prasad, R, Wang, H, Boldogh, I, Karimi-Busheri, F, Weinfeld, M, Tomkinson, AE, Wilson, SH, Mitra, S, Hazra, TK	DNA Repair (Amst.)	2006
15260972	AP endonuclease-independent DNA base excision repair in human cells Wiederhold, L, Leppard, JB, Kedar, P, Karimi-Busheri, F, Rasouli-Nia, A, Weinfeld, M, Tomkinson, AE, Izumi, T, Prasad, R, Wilson, SH, Mitra, S, Hazra, TK	Mol. Cell	2004