NEIL1 cleaves FapyG from damaged DNA

Stable Identifier
R-HSA-5649664
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NEIL1 acts as a DNA glycosylase to remove FapyG from damaged DNA, producing an AP (apurinic/apyrimidinic) site (Hazra et al. 2002).

Literature References
PubMed ID Title Journal Year
11904416 Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

Hazra, TK, Izumi, T, Boldogh, I, Imhoff, B, Kow, YW, Jaruga, P, Dizdaroglu, M, Mitra, S

Proc. Natl. Acad. Sci. U.S.A. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA N-glycosylase activity of NEIL1:FapyG-dsDNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created