NEIL1 recognizes and binds DHU-dsDNA

Stable Identifier
R-HSA-5649655
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEIL1 recognizes and binds DHU-dsDNA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NEIL1 (endonuclease 8-like protein 1), an enzyme with dual DNA glycosylase and beta/delta lyase activity, recognizes and binds DNA damage in the form of dihydrouracil (DHU) (Hazra et al. 2002). 5,6-dihydrouracil is a form of DNA damage produced by ionizing radiation under anoxic conditions, so that cytosine is deaminated and C5-C6 double bond in the pyrimidine ring is saturated with hydrogen. 5,6-dihydrouracil mispairs with adenine, leading to G:C -> A:T transitions (Dizdaroglu et al. 1993).
Literature References
PubMed ID Title Journal Year
11904416 Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

Dizdaroglu, M, Imhoff, B, Kow, YW, Mitra, S, Izumi, T, Jaruga, P, Hazra, TK, Boldogh, I

Proc. Natl. Acad. Sci. U.S.A. 2002
8218289 Substrate specificity of the Escherichia coli endonuclease III: excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals

Laval, J, Boiteux, S, Dizdaroglu, M

Biochemistry 1993
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Authored
Orlic-Milacic, M  (2014-12-04)
Reviewed
Borowiec, JA  (2014-12-22)
Sampath, H  (2019-01-03)
Created
Orlic-Milacic, M  (2014-11-21)
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