NEIL1 recognizes and binds DHU-dsDNA

Stable Identifier
R-HSA-5649655
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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NEIL1 (endonuclease 8-like protein 1), an enzyme with dual DNA glycosylase and beta/delta lyase activity, recognizes and binds DNA damage in the form of dihydrouracil (DHU) (Hazra et al. 2002). 5,6-dihydrouracil is a form of DNA damage produced by ionizing radiation under anoxic conditions, so that cytosine is deaminated and C5-C6 double bond in the pyrimidine ring is saturated with hydrogen. 5,6-dihydrouracil mispairs with adenine, leading to G:C -> A:T transitions (Dizdaroglu et al. 1993).

Literature References
PubMed ID Title Journal Year
8218289 Substrate specificity of the Escherichia coli endonuclease III: excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals

Dizdaroglu, M, Laval, J, Boiteux, S

Biochemistry 1993
11904416 Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

Hazra, TK, Izumi, T, Boldogh, I, Imhoff, B, Kow, YW, Jaruga, P, Dizdaroglu, M, Mitra, S

Proc. Natl. Acad. Sci. U.S.A. 2002
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