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SPRTN [nucleoplasm]
Stable Identifier
R-HSA-5643744
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SprT-like domain-containing protein Spartan, C1orf124, Spartan, DVC1
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Translesion Synthesis by POLH (Homo sapiens)
SPRTN binds monoUb:K164-PCNA associated with POLH (Homo sapiens)
SPRTN [nucleoplasm] (Homo sapiens)
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
SPRTN [nucleoplasm] (Homo sapiens)
SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Homo sapiens)
NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
SPRTN [nucleoplasm] (Homo sapiens)
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
SPRTN [nucleoplasm] (Homo sapiens)
SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Homo sapiens)
NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
SPRTN [nucleoplasm] (Homo sapiens)
NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA [nucleoplasm] (Homo sapiens)
SPRTN [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H040 SPRTN
Gene Names
SPRTN, C1orf124, DVC1, UNQ1880/PRO4323
Chain
chain:1-489
Reference Genes
BioGPS Gene:83932 SPRTN
COSMIC (genes):SPRTN SPRTN
CTD Gene:83932 SPRTN
dbSNP Gene:83932 SPRTN
ENSEMBL:ENSG00000010072 SPRTN
HGNC:25356 SPRTN
KEGG Gene (Homo sapiens):83932 SPRTN
Monarch:83932 SPRTN
NCBI Gene:83932 SPRTN
OMIM:616086 SPRTN
UCSC:Q9H040 SPRTN
Reference Transcript
RefSeq:NM_001010984.3 SPRTN
RefSeq:NM_001261462.2 SPRTN
RefSeq:NM_032018.6 SPRTN
Other Identifiers
0006760671
11729674_a_at
11729675_a_at
16678738
223511_at
2385259
2385260
2385261
2385262
2385265
2385269
2385270
2385274
2385275
2385276
2385277
2385278
2385279
45397_i_at
45398_r_at
50598_at
70940_at
7910539
81787_i_at
81788_r_at
83932
86230_at
A_23_P433791
A_24_P15292
GE56451
GE83295
GO:0003674
GO:0003677
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0006259
GO:0006281
GO:0006464
GO:0006950
GO:0006974
GO:0008150
GO:0009058
GO:0009411
GO:0016607
GO:0019985
GO:0031398
GO:0031593
GO:0032182
GO:0034641
GO:0043130
GO:0043167
GO:0043226
GO:0046872
GO:0070530
GO:0070987
ILMN_1655485
ILMN_1759464
ILMN_2371470
PH_hs_0002114
PH_hs_0040455
TC01001916.hg
g12224895_3p_at
Participant Of
input
SPRTN binds monoUb:K164-PCNA associated with POLH
hasComponent
NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA [nucleoplasm]
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm]
Inferred To
sprtn [nucleoplasm] (Danio rerio)
sprtn [nucleoplasm] (Xenopus tropicalis)
Ghost homologue of SPRTN [nucleoplasm] (Schizosaccharomyces pombe)
SPRTN [nucleoplasm] (Bos taurus)
SPRTN [nucleoplasm] (Canis familiaris)
SPRTN [nucleoplasm] (Gallus gallus)
SPRTN [nucleoplasm] (Sus scrofa)
Sprtn [nucleoplasm] (Mus musculus)
Sprtn [nucleoplasm] (Rattus norvegicus)
mh [nucleoplasm] (Drosophila melanogaster)
dvc-1 [nucleoplasm] (Caenorhabditis elegans)
Cross References
RefSeq
NP_001248391.1
,
NP_114407.3
,
NP_001010984.1
OpenTargets
ENSG00000010072
GeneCards
Q9H040
HPA
ENSG00000010072-SPRTN
Ensembl
ENST00000295050
,
ENSP00000008440
,
ENST00000391858
,
ENST00000008440
,
ENSP00000295050
,
ENSG00000010072
,
ENSP00000375731
PRO
Q9H040
Orphanet
23508
PDB
6MDW
,
5IY4
,
6MDX
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