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CRY2 gene [nucleoplasm]
Stable Identifier
R-HSA-5641201
Type
DNA Sequence [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Circadian clock (Homo sapiens)
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes (Homo sapiens)
Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Cryptochrome-2 (CRY2) (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the CRY2 gene (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters (Homo sapiens)
CLOCK acetylates BMAL1 on lysine-538 (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
p-T451,T461-CLOCK is phosphorylated on serines-440,441,446 (Homo sapiens)
p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex (Homo sapiens)
CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-K538-BMAL1:p-3S,2T-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-K538-BMAL1:p-4S,2T-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-4S,2T-CLOCK:Target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-S,T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E binds p-S90,Ac-K538-BMAL1:p-2T,3S-CLOCK:target gene (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-K538-BMAL1:p-3S,2T-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL1:p-4S,2T-CLOCK dissociates from target gene (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-K538-BMAL1:p-4S,2T-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-4S,2T-CLOCK:Target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-S,T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
CRY2 gene [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
ENSEMBL:ENSG00000121671 CRY2
Gene Names
CRY2, KIAA0658
Participates
as a component of
p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-S,T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
as an input of
Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Cryptochrome-2 (CRY2) (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the CRY2 gene (Homo sapiens)
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