EZH2 (KMT6, PRC2) is the catalytic subunit of the PRC2 (EZH2) Core complex, which additionally contains EED, SUZ12, AEBP2 and one of RBBP4 or RBBP7. It methylates lysine-28 (H3K27) of histone H3 (Cao et al. 2002, Czermin et al. 2002, Kuzmichev et al. 2002, Muller et al. 2002) leading to transcriptional repression of the affected target gene. It is able to mono-, di- and trimethylate lysine-28 (Cao & Zhang 2004).