PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)

Stable Identifier
R-HSA-5638332
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3
ReviewStatus
5/5
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PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)
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EZH2 (KMT6, PRC2) is the catalytic subunit of the PRC2 (EZH2) Core complex, which additionally contains EED, SUZ12, AEBP2 and one of RBBP4 or RBBP7. It methylates lysine-28 (H3K27) of histone H3 (Cao et al. 2002, Czermin et al. 2002, Kuzmichev et al. 2002, Muller et al. 2002) leading to transcriptional repression of the affected target gene. It is able to mono-, di- and trimethylate lysine-28 (Cao & Zhang 2004).
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Catalyst Activity

histone H3 methyltransferase activity of PRC2 (EZH2) Core:AEBP2 [nucleoplasm]

Physical Entity
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Homo sapiens)
Activity
histone H3 methyltransferase activity (GO:0140938)
Orthologous Events
PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Bos taurus)
PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Canis familiaris)
PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Mus musculus)
PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)
PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)
Authored
Jupe, S  (2014-11-13)
Reviewed
Motamedi, M  (2014-11-17)
Created
Jupe, S  (2014-11-13)
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