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Signaling by Overexpressed Wild-Type EGFR in Cancer
Stable Identifier
R-HSA-5638302
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by Overexpressed Wild-Type EGFR in Cancer (Homo sapiens)
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Signaling by EGFR is frequently activated in cancer through genomic amplification of the EGFR locus, resulting in over-expression of the wild-type protein (Wong et al. 1987).
Literature References
PubMed ID
Title
Journal
Year
3477813
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification
Vogelstein, B
,
Bigner, SH
,
Bigner, DD
,
Kinzler, KW
,
Hamilton, SR
,
Wong, AJ
Proc. Natl. Acad. Sci. U.S.A.
1987
Participants
Events
Inhibition of Signaling by Overexpressed EGFR
(Homo sapiens)
Participates
as an event of
Signaling by EGFR in Cancer (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M (2011-11-04)
Reviewed
Greulich, H (2011-11-15)
Savas, S (2011-11-15)
Created
Orlic-Milacic, M (2014-11-13)
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