Signaling by Overexpressed Wild-Type EGFR in Cancer

Stable Identifier
R-HSA-5638302
Type
Pathway
Species
Homo sapiens
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Signaling by EGFR is frequently activated in cancer through genomic amplification of the EGFR locus, resulting in over-expression of the wild-type protein (Wong et al. 1987).

Literature References
PubMed ID Title Journal Year
3477813 Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification

Wong, AJ, Bigner, SH, Bigner, DD, Kinzler, KW, Hamilton, SR, Vogelstein, B

Proc. Natl. Acad. Sci. U.S.A. 1987
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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