SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36)

Stable Identifier
R-HSA-5638141
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SETD2 (KMT3A) methylates Me2K37-histone H3 (H3K36), SETD2 methylates Me2K37-histone H3
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SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36)
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SETD2 (KMT3A) trimethylates lysine-37 of histone H3 (H3K36) (Sun et al. 2005) and is thought to be the sole H3K36 methyltransferase in vivo (Edmunds et al. 2008, Yuan et al. 2009).

Literature References
PubMed ID Title Journal Year
16118227 Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase

Wang, L, Chen, Z, Wang, HH, Wei, J, Huang, QH, Wu, XY, Hu, M, Sun, XJ, Zhang, QH, Chen, SJ

J. Biol. Chem. 2005
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Catalyst Activity

histone-lysine N-methyltransferase activity of SETD2 [nucleoplasm]

Physical Entity
SETD2 [nucleoplasm] (Homo sapiens)
Activity
histone-lysine N-methyltransferase activity (GO:0018024)
Orthologous Events
SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Bos taurus)
SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Canis familiaris)
SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Danio rerio)
SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Mus musculus)
SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Rattus norvegicus)
SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Sus scrofa)
SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)
Authored
Jupe, S  (2013-03-12)
Reviewed
Motamedi, M  (2014-11-17)
Created
Jupe, S  (2014-11-13)
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