SETD2 (KMT3A) trimethylates lysine-37 of histone H3 (H3K36) (Sun et al. 2005) and is thought to be the sole H3K36 methyltransferase in vivo (Edmunds et al. 2008, Yuan et al. 2009).
histone-lysine N-methyltransferase activity of SETD2 [nucleoplasm]