Reactome | CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body

CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body

Stable Identifier

R-HSA-5638009

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body

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The distal appendage protein CEP164 interacts with RAB3IP, and in this way recruits Golgi-derived vesicles to the basal body to initiate ciliary membrane biogenesis (Schmidt et al, 2012; Westlake et al, 2011; Rohatgi and Snell, 2010). RAB3IP recruitment to the distal appendages of centrioles promotes the appropriate localization and activation of RAB8A (Nachury et al, 2007; Yoshimura et al, 2007; Westlake et al, 2011; Schmidt et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
23253480	Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis Schmidt, KN, Kuhns, S, Neuner, A, Hub, B, Zentgraf, H, Pereira, G	J. Cell Biol.	2012
17646400	Functional dissection of Rab GTPases involved in primary cilium formation Yoshimura, S, Egerer, J, Fuchs, E, Haas, AK, Barr, FA	J. Cell Biol.	2007
20399632	The ciliary membrane Rohatgi, R, Snell, WJ	Curr. Opin. Cell Biol.	2010
21273506	Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome Westlake, CJ, Baye, LM, Nachury, MV, Wright, KJ, Ervin, KE, Phu, L, Chalouni, C, Beck, JS, Kirkpatrick, DS, Slusarski, DC, Sheffield, VC, Scheller, RH, Jackson, PK	Proc. Natl. Acad. Sci. U.S.A.	2011
17574030	A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis Nachury, MV, Loktev, AV, Zhang, Q, Westlake, CJ, Peränen, J, Merdes, A, Slusarski, DC, Scheller, RH, Bazan, JF, Sheffield, VC, Jackson, PK	Cell	2007