CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body

Stable Identifier
Reaction [binding]
Homo sapiens
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The distal appendage protein CEP164 interacts with RAB3IP, and in this way recruits Golgi-derived vesicles to the basal body to initiate ciliary membrane biogenesis (Schmidt et al, 2012; Westlake et al, 2011; Rohatgi and Snell, 2010). RAB3IP recruitment to the distal appendages of centrioles promotes the appropriate localization and activation of RAB8A (Nachury et al, 2007; Yoshimura et al, 2007; Westlake et al, 2011; Schmidt et al, 2012).

Literature References
PubMed ID Title Journal Year
23253480 Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis

Hub, B, Neuner, A, Zentgraf, H, Kuhns, S, Schmidt, KN, Pereira, G

J. Cell Biol. 2012
17646400 Functional dissection of Rab GTPases involved in primary cilium formation

Barr, FA, Haas, AK, Egerer, J, Yoshimura, S, Fuchs, E

J. Cell Biol. 2007
20399632 The ciliary membrane

Snell, WJ, Rohatgi, R

Curr. Opin. Cell Biol. 2010
21273506 Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

Kirkpatrick, DS, Scheller, RH, Ervin, KE, Wright, KJ, Slusarski, DC, Nachury, MV, Westlake, CJ, Baye, LM, Sheffield, VC, Chalouni, C, Jackson, PK, Beck, JS, Phu, L

Proc. Natl. Acad. Sci. U.S.A. 2011
17574030 A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

Westlake, CJ, Loktev, AV, Zhang, Q, Sheffield, VC, Scheller, RH, Slusarski, DC, Nachury, MV, Jackson, PK, Peränen, J, Bazan, JF, Merdes, A

Cell 2007
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