SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)

Stable Identifier
R-HSA-5637808
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SOS1 is the guanine nucleotide exchange factor (GEF) for RAS. SOS1, recruited by GRB2 bound to p-SHC1:p-EGFRvIII mutant, is assumed to activate RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP). Although this reaction has not been shown to occur directly for EGFRvIII cancer mutant, activation of RAF/MAP kinase cascade has been demonstrated in cells expressing EGFRvIII (Montgomery et al. 1995).

Literature References
PubMed ID Title Journal Year
8530489 Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor

Montgomery, RB, Moscatello, DK, Wong, AJ, Cooper, JA, Stahl, WL

J. Biol. Chem. 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]
Physical Entity
Activity
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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