Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII

Stable Identifier
R-HSA-5637801
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII
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The kinase activity of PI3K mediates the phosphorylation of PIP2 to form PIP3. It is assumed that EGFRvIII cancer mutant induces PI3K/AKT signaling in a manner similar to wild-type EGFR. Accordingly, activation of PI3K/AKT signaling cascade has been demonstrated in cells expressing EGFRvIII (Lammering et al. 2003, Li et al. 2004)

Literature References
PubMed ID Title Journal Year
12944901 EGFRvIII-mediated radioresistance through a strong cytoprotective response

Hewit, TH, Amorino, GP, Valerie, K, Schmidt-Ullrich, RK, Lammering, G, Dent, P, Contessa, JN

Oncogene 2003
15077177 Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin

Shu, HK, Kim, IA, Chang, CM, Bernhard, EJ, Li, B, Yuan, M

Oncogene 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane]

Physical Entity
p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Normal reaction
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
Functional status

Gain of function of p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Rhea
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2014-11-13)
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