Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII

Stable Identifier
R-HSA-5637801
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The kinase activity of PI3K mediates the phosphorylation of PIP2 to form PIP3. It is assumed that EGFRvIII cancer mutant induces PI3K/AKT signaling in a manner similar to wild-type EGFR. Accordingly, activation of PI3K/AKT signaling cascade has been demonstrated in cells expressing EGFRvIII (Lammering et al. 2003, Li et al. 2004)

Literature References
PubMed ID Title Journal Year
15077177 Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin

Li, B, Yuan, M, Kim, IA, Chang, CM, Bernhard, EJ, Shu, HK

Oncogene 2004
12944901 EGFRvIII-mediated radioresistance through a strong cytoprotective response

Lammering, G, Hewit, TH, Valerie, K, Contessa, JN, Amorino, GP, Dent, P, Schmidt-Ullrich, RK

Oncogene 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane]
Physical Entity
Activity
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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