Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII

Stable Identifier
R-HSA-5637765
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII
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EGFRvIII cancer mutant is assumed to recruit the PI3K complex PIK3CA:PIK3R1 in a manner similar to wild-type EGFR (Rodrigues et al. 2000).
Literature References
PubMed ID Title Journal Year
10648629 A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

Rodrigues, GA, Falasca, M, Zhang, Z, Ong, SH, Schlessinger, J

Mol Cell Biol 2000
Participants
Input
Output
Participates
as an event of
Normal reaction
PI3K binds to EGF:EGFR:GRB2:GAB1 (Homo sapiens)
Functional status

Gain of function of p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2014-11-13)
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