Reactome | ub-GLI is degraded by the proteasome

ub-GLI is degraded by the proteasome

Stable Identifier

R-HSA-5635868

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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After NUMB:ITCH-mediated ubiquitination, GLI1 is degraded by the proteasome. This degradation limits the extent and duration of the response to Hh signaling (di Marcotullio et al, 2006; Huntzicker et al, 2006; di Marcotullio et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
16421275	Dual degradation signals control Gli protein stability and tumor formation Huntzicker, EG, Estay, IS, Zhen, H, Lokteva, LA, Jackson, PK, Oro, AE	Genes Dev.	2006
17115028	Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination Di Marcotullio, L, Ferretti, E, Greco, A, De Smaele, E, Po, A, Sico, MA, Alimandi, M, Giannini, G, Maroder, M, Screpanti, I, Gulino, A	Nat. Cell Biol.	2006
20818436	Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal Di Marcotullio, L, Greco, A, Mazzà, D, Canettieri, G, Pietrosanti, L, Infante, P, Coni, S, Moretti, M, De Smaele, E, Ferretti, E, Screpanti, I, Gulino, A	Oncogene	2011