Reactome | GLI2,3 are degraded by the proteasome

GLI2,3 are degraded by the proteasome

Stable Identifier

R-HSA-5635854

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SPOP:CUL3:RBX1-mediated ubiquitination of the transcriptionally active GLI proteins attenuates Hh-dependent signaling by promoting their degradation by the proteasome (Zhang et al, 2009; Chen et al, 2009; Humke et al, 2010; Tukachinsky et al, 2010; Wen et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
19955409	Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase Yue, T, Li, S, Zhang, Q, Wang, B, Shi, Q, Jiang, J, Chen, Y	Proc. Natl. Acad. Sci. U.S.A.	2009
20154143	Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation Scales, SJ, Hongo, JA, Wen, X, Evangelista, M, Lai, CK, de Sauvage, FJ	Mol. Cell. Biol.	2010
19684112	Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved Li, YJ, Zhang, X, Hui, CC, Chuang, PT, Gacayan, R, Law, KK, Wilson, CW, Lu, CS, Chen, MH	Genes Dev.	2009
20360384	The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins Milenkovic, L, Rohatgi, R, Scott, MP, Humke, EW, Dorn, KV	Genes Dev.	2010
20956384	A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes Salic, A, Lopez, LV, Tukachinsky, H	J. Cell Biol.	2010