ULK3 phosphorylates GLI

Stable Identifier
Reaction [transition]
Homo sapiens
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Dissociation from SUFU allows the STK36/dFu homologue ULK3 to phosphorylate full-length GLI proteins. Phosphorylation promotes the nuclear translocation of the proteins and stimulates the transcription factor activity as assessed by a GLI-responsive reporter gene. In vitro, ULK3 phosphorylates GLI2 with the highest efficiency, but the kinase is also able to phosphorylate GLI1 and GLI3 (Maloverjan et al, 2010a; Maloverjan et al, 2010b). ULK3 is only one of a number of kinases that have been implicated in the regulation of GLI proteins in response to pathway stimulation, and how all the putative regulators interact to control GLI transcriptional activity remains to be elucidated (Evangelista et al, 2008; Mao et al, 2002; Varjosalo et al, 2008; reviewed in Marjosalo and Piirsoo, 2012).

Literature References
PubMed ID Title Journal Year
18827223 Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction

Davis, DP, Ye, W, Ashique, A, Parker, L, Lee, J, Evangelista, M, Peterson, AS, Lim, TY, de Sauvage, FJ

Sci Signal 2008
12138125 Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1

Wu, G, Kogerman, P, Maye, P, Tejedor, FJ, Xie, W, Mao, J, Toftgard, R, Wu, D

J. Biol. Chem. 2002
22391301 Mammalian homologues of Drosophila fused kinase

Piirsoo, M, Maloverjan, A

Vitam. Horm. 2012
20643644 Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway

Kogerman, P, Kasak, L, Piirsoo, M, Maloverjan, A, Østerlund, T, Peil, L

J. Biol. Chem. 2010
12050670 Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

Mechler, BM, Wu, W, Li, M, Marhold, J, Niehrs, C, Stannek, P, Mao, B, Delius, H, Walter, C, Hoppe, D, Davidson, G, Glinka, A

Nature 2002
18455992 Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

Björklund, M, Varjosalo, M, Kivioja, T, Syvänen, H, Kilpinen, S, Kallioniemi, O, Taipale, J, Sun, Z, Stunnenberg, HG, He, WW, Cheng, F, Ojala, P

Cell 2008
19878745 Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway

Kogerman, P, Osterlund, T, Piirsoo, M, Maloverjan, A, Michelson, P

Exp. Cell Res. 2010
Catalyst Activity

protein serine/threonine kinase activity of ULK3 [ciliary tip]

Orthologous Events
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