Reactome | ULK3 phosphorylates GLI

ULK3 phosphorylates GLI

Stable Identifier

R-HSA-5635842

Type

Reaction

Species

Homo sapiens

Compartment

ciliary tip

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Dissociation from SUFU allows the STK36/dFu homologue ULK3 to phosphorylate full-length GLI proteins. Phosphorylation promotes the nuclear translocation of the proteins and stimulates the transcription factor activity as assessed by a GLI-responsive reporter gene. In vitro, ULK3 phosphorylates GLI2 with the highest efficiency, but the kinase is also able to phosphorylate GLI1 and GLI3 (Maloverjan et al, 2010a; Maloverjan et al, 2010b). ULK3 is only one of a number of kinases that have been implicated in the regulation of GLI proteins in response to pathway stimulation, and how all the putative regulators interact to control GLI transcriptional activity remains to be elucidated (Evangelista et al, 2008; Mao et al, 2002; Varjosalo et al, 2008; reviewed in Marjosalo and Piirsoo, 2012).

Literature References

PubMed ID	Title	Journal	Year
18827223	Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction Davis, DP, Ye, W, Ashique, A, Parker, L, Lee, J, Evangelista, M, Peterson, AS, Lim, TY, de Sauvage, FJ	Sci Signal	2008
12138125	Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1 Wu, G, Kogerman, P, Maye, P, Tejedor, FJ, Xie, W, Mao, J, Toftgard, R, Wu, D	J. Biol. Chem.	2002
22391301	Mammalian homologues of Drosophila fused kinase Piirsoo, M, Maloverjan, A	Vitam. Horm.	2012
20643644	Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway Kogerman, P, Kasak, L, Piirsoo, M, Maloverjan, A, Østerlund, T, Peil, L	J. Biol. Chem.	2010
12050670	Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling Mechler, BM, Wu, W, Li, M, Marhold, J, Niehrs, C, Stannek, P, Mao, B, Delius, H, Walter, C, Hoppe, D, Davidson, G, Glinka, A	Nature	2002
18455992	Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling Björklund, M, Varjosalo, M, Kivioja, T, Syvänen, H, Kilpinen, S, Kallioniemi, O, Taipale, J, Sun, Z, Stunnenberg, HG, He, WW, Cheng, F, Ojala, P	Cell	2008
19878745	Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway Kogerman, P, Osterlund, T, Piirsoo, M, Maloverjan, A, Michelson, P	Exp. Cell Res.	2010