Reactome | MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)

MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)

Stable Identifier

R-HSA-5634802

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MECOM, PRDM16 methylate lysine-10 of replicative histone H3

ReviewStatus

5/5

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MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)

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MECOM (KMT8E, PRDM3) and PRDM16 (KMT8F) are histone 3 lysine-10 (H3K9) methyltransferases responsible for cytoplasmic H3K9 mono-methylation.

Literature References

PubMed ID	Title	Journal	Year
22939622	Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity Pinheiro, I, Margueron, R, Shukeir, N, Eisold, M, Fritzsch, C, Richter, FM, Mittler, G, Genoud, C, Goyama, S, Kurokawa, M, Son, J, Reinberg, D, Lachner, M, Jenuwein, T	Cell	2012