EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9)

Stable Identifier
Reaction [transition]
Homo sapiens
EHMT1:EHMT2 methylates lysine-10 of histone H3
Locations in the PathwayBrowser
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EHMT2 (KMT1C, G9A) and EHMT1 (KMT1D, GLP) are the euchromatic histone H3 lysine-10 (H3K9) mono and di-methyltransferases in mammals (Tachibana et al. 2002, Rice et al. 2003, Tachibana et al. 2005). In vivo they exist predominantly as a heteromeric complex together with WIZ, a multi-zinc finger protein, (Ueda et al. 2006) and are responsible for global H3K9 mono- and di-methylation (Shinkai & Tchibana 2011).

Literature References
PubMed ID Title Journal Year
14690610 Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

Shinkai, Y, Shabanowitz, J, Hunt, DF, Briggs, SD, Allis, CD, Ueberheide, B, Rice, JC, Barber, CM

Mol Cell 2003
12130538 G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

Sugimoto, K, Niida, H, Shinkai, Y, Ohta, T, Fukuda, M, Tachibana, M, Ohki, M, Ueda, J, Kato, H, Takeda, N, Nozaki, M

Genes Dev. 2002
Catalyst Activity

histone-lysine N-methyltransferase activity of EHMT1:EHMT2 [nucleoplasm]

Orthologous Events
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