Reactome | SUMO-CRABP2:atRA translocates from cytosol to nucleus

SUMO-CRABP2:atRA translocates from cytosol to nucleus

Stable Identifier

R-HSA-5634104

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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SUMO-CRABP2:atRA translocates from cytosol to nucleus

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Cellular retinoic acid-binding protein 2 (CRABP2) is a cytosolic, lipid-binding protein thought to bind its natural ligand, all-trans-retinoic acid (atRA) and mediate its delivery to retinoic acid receptors (RARs) within the nucleus (Kleywegt et al. 1994). CRABP2 forms a beta-barrel structure within which a hydrophobic ligand can be accommodated. Once atRA binds to CRABP2, the resulting complex translocates to the nucleus (Budhu & Noy 2002). A ligand activated nuclear-localisation signal appears to be critical for nuclear localisation (Sessler & Noy 2005). Sumoylation of CRABPs is also essential for atRA-induced dissociation of CRABPs from the ER membrane. For CRABP2, the site K102 is sumoylated (Majumdar et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
11909957	Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest Noy, N, Budhu, AS	Mol. Cell. Biol.	2002
7704533	Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid Jones, TA, Bergfors, T, Gsell, B, Le Motte, P, Senn, H, Kleywegt, GJ, Shudo, K	Structure	1994
21998312	Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation Noy, N, Majumdar, A, Petrescu, AD, Xiong, Y	J. Biol. Chem.	2011
15866176	A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II Noy, N, Sessler, RJ	Mol. Cell	2005