TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes

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R-HSA-5633441
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Reaction [omitted]
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Homo sapiens
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TP53 (p53) directly stimulates transcription of genes encoding TRAIL (TNF-related apoptosis-inducing ligand) receptors, also known as death receptors, TNFRSF10A (DR4) (Guan et al. 2001, Liu et al. 2004), TNFRSF10B (DR5) (Wu et al. 1997, Takimoto et al. 2000), TNFRSF10C (DCR1) (Ruiz de Almodovar et al. 2004) and TNFRSF10D (DCR2) (Liu et al. 2005). These receptors are involved in TRAIL signaling, which constitutes a part of the extrinsic apoptotis pathway.

Literature References
PubMed ID Title Journal Year
15289308 p53 upregulates death receptor 4 expression through an intronic p53 binding site

Liu, X, Yue, P, Khuri, FR, Sun, SY

Cancer Res. 2004
14623878 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site

Ruiz de Almodóvar, C, Ruiz-Ruiz, C, Rodríguez, A, Ortiz-Ferrón, G, Redondo, JM, López-Rivas, A

J. Biol. Chem. 2004
11382926 Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene

Guan, B, Yue, P, Clayman, GL, Sun, SY

J. Cell. Physiol. 2001
10777207 Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

Takimoto, R, el-Deiry, WS

Oncogene 2000
9326928 KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

Wu, GS, Burns, TF, McDonald, ER, Jiang, W, Meng, R, Krantz, ID, Kao, G, Gan, DD, Zhou, JY, Muschel, R, Hamilton, SR, Spinner, NB, Markowitz, S, Wu, G, el-Deiry, WS

Nat. Genet. 1997
16230375 Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity

Liu, X, Yue, P, Khuri, FR, Sun, SY

Cancer Res. 2005
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