CSNK1A1 and ADRBK1 dissociate from p-SMO dimer

Stable Identifier
R-HSA-5633040
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
ciliary membrane
ReviewStatus
5/5
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CSNK1A1 and ADRBK1 dissociate from p-SMO dimer
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After phosphorylating the SMO dimer, CSNK1A1 and ADRBK1 presumably dissociate, although this has not been demonstrated explicitly (Chen et al, 2011).

Literature References
PubMed ID Title Journal Year
21695114 Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothened

Yue, T, Jia, J, Ma, G, Sasai, N, Briscoe, J, Jiang, J, Chen, Y

PLoS Biol. 2011
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Orthologous Events
CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Bos taurus)
CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Canis familiaris)
CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Danio rerio)
CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Drosophila melanogaster)
CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Gallus gallus)
CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Mus musculus)
CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Rattus norvegicus)
CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Sus scrofa)
CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Xenopus tropicalis)
Authored
Rothfels, K  (2014-10-28)
Reviewed
Liu, Y C  (2014-11-09)
Created
Rothfels, K  (2014-10-30)
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