TP53 binds the GLS2 promoter

Stable Identifier
R-HSA-5632914
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The mitochondrial glutaminase GLS2 gene possesses two putative p53-binding sites in its promoter and one putative p53 binding site in the first intron. TP53 was demonstrated to bind to p53-response elements in the promoter but not intron 1 of GLS2 (Hu et al. 2010, Suzuki et al. 2010).

Literature References
PubMed ID Title Journal Year
20351271 Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Suzuki, S, Tanaka, T, Poyurovsky, MV, Nagano, H, Mayama, T, Ohkubo, S, Lokshin, M, Hosokawa, H, Nakayama, T, Suzuki, Y, Sugano, S, Sato, E, Nagao, T, Yokote, K, Tatsuno, I, Prives, C

Proc. Natl. Acad. Sci. U.S.A. 2010
20378837 Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Hu, W, Zhang, C, Wu, R, Sun, Y, Levine, A, Feng, Z

Proc. Natl. Acad. Sci. U.S.A. 2010
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