TP53 binds the GLS2 promoter

Stable Identifier
R-HSA-5632914
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TP53 binds the GLS2 promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The mitochondrial glutaminase GLS2 gene possesses two putative p53-binding sites in its promoter and one putative p53 binding site in the first intron. TP53 was demonstrated to bind to p53-response elements in the promoter but not intron 1 of GLS2 (Hu et al. 2010, Suzuki et al. 2010).

Literature References
PubMed ID Title Journal Year
20378837 Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Zhang, C, Hu, W, Sun, Y, Wu, R, Levine, A, Feng, Z

Proc. Natl. Acad. Sci. U.S.A. 2010
20351271 Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Hosokawa, H, Poyurovsky, MV, Nagano, H, Mayama, T, Tanaka, T, Prives, C, Nakayama, T, Sato, E, Ohkubo, S, Lokshin, M, Suzuki, S, Nagao, T, Suzuki, Y, Yokote, K, Sugano, S, Tatsuno, I

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
Input
Output
Participates
as an event of
Authored
Orlic-Milacic, M  (2014-12-23)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Wang, PY  (2014-12-30)
Hwang, PM  (2014-12-30)
Kang, JG  (2014-12-30)
Created
Orlic-Milacic, M  (2014-10-29)
Cite Us!