TP53 stimulates SCO2 gene transcription

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R-HSA-5632766
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Reaction [omitted]
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Homo sapiens
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TP53 (p53) directly stimulates transcription of the SCO2 gene. SCO2, synthesis of cytochrome c oxidase 2, is a copper-binding assembly protein for the mitochondrial COX (cytochrome C oxidase) complex which enables aerobic respiration. When SCO2 levels are reduced, as occurs in TP53 deficient cells, the glycolysis becomes the main energy source for the cell. The TP53-mediated regulation of SCO2 and other mitochondrial biogenesis genes provides a possible explanation for the Warburg effect (Warburg 1956) observed in some cancer cells (Matoba et al. 2006).

Literature References
PubMed ID Title Journal Year
16728594 p53 regulates mitochondrial respiration

Matoba, S, Kang, JG, Patino, WD, Wragg, A, Boehm, M, Gavrilova, O, Hurley, PJ, Bunz, F, Hwang, PM

Science 2006
13298683 On the origin of cancer cells

WARBURG, O

Science 1956
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