TP53 stimulates SCO2 gene transcription

Stable Identifier
R-HSA-5632766
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
mitochondrial matrix, nucleoplasm
ReviewStatus
5/5
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TP53 stimulates SCO2 gene transcription
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TP53 (p53) directly stimulates transcription of the SCO2 gene. SCO2, synthesis of cytochrome c oxidase 2, is a copper-binding assembly protein for the mitochondrial COX (cytochrome C oxidase) complex which enables aerobic respiration. When SCO2 levels are reduced, as occurs in TP53 deficient cells, the glycolysis becomes the main energy source for the cell. The TP53-mediated regulation of SCO2 and other mitochondrial biogenesis genes provides a possible explanation for the Warburg effect (Warburg 1956) observed in some cancer cells (Matoba et al. 2006).
Literature References
PubMed ID Title Journal Year
13298683 On the origin of cancer cells

WARBURG, O

Science 1956
16728594 p53 regulates mitochondrial respiration

Matoba, S, Kang, JG, Patino, WD, Wragg, A, Boehm, M, Gavrilova, O, Hurley, PJ, Bunz, F, Hwang, PM

Science 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TP53 Tetramer:SCO2 Gene [nucleoplasm] (Homo sapiens)
Active Unit
TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2014-12-23)
Reviewed
Hwang, PM  (2014-12-30)
Kang, JG  (2014-12-30)
Wang, PY  (2014-12-30)
Inga, A  (2016-02-04)
Zaccara, S  (2016-02-04)
Created
Orlic-Milacic, M  (2014-10-29)
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