TP53 binds the SCO2 gene

Stable Identifier
R-HSA-5632759
Type
Reaction [binding]
Species
Homo sapiens
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TP53 (p53) binds the p53 response element in the intron 1 of SCO2 (Synthesis of Cytochrome c Oxidase 2) gene (Matoba et al. 2006). The binding of TP53 on SCO2 gene was verified in a genome wide chromatin immunoprecipitation study (Wei et al. 2006). Tp53 was also found to bind to the promoter region in mouse Sco2 gene to stimulate its expression in response to physical exercise (Qi et al. 2011).

Literature References
PubMed ID Title Journal Year
16413492 A global map of p53 transcription-factor binding sites in the human genome

Wei, CL, Wu, Q, Vega, VB, Chiu, KP, Ng, P, Zhang, T, Shahab, A, Yong, HC, Fu, Y, Weng, Z, Liu, J, Zhao, XD, Chew, JL, Lee, YL, Kuznetsov, VA, Sung, WK, Miller, LD, Lim, B, Liu, ET, Yu, Q, Ng, HH, Ruan, Y

Cell 2006
16728594 p53 regulates mitochondrial respiration

Matoba, S, Kang, JG, Patino, WD, Wragg, A, Boehm, M, Gavrilova, O, Hurley, PJ, Bunz, F, Hwang, PM

Science 2006
21750704 Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age

Qi, Z, He, J, Su, Y, He, Q, Liu, J, Yu, L, Al-Attas, O, Hussain, T, Ding, S, Ji, L, Qian, M

PLoS ONE 2011
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