SMO dimer binds ARRB and KIF3A

Stable Identifier
R-HSA-5632667
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Beta-arrestin 1 and 2 (ARRB1 and 2) and the anterograde motor protein KIF3A bind to SMO and may be required for its ciliary accumulation after Hh stimulation (Kovacs et al, 2008; Barakat et al, 2013).

Literature References
PubMed ID Title Journal Year
18497258 Beta-arrestin-mediated localization of smoothened to the primary cilium

Kovacs, JJ, Whalen, EJ, Liu, R, Xiao, K, Kim, J, Chen, M, Wang, J, Chen, W, Lefkowitz, RJ

Science 2008
23877428 Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

Barakat, B, Yu, L, Lo, C, Vu, D, De Luca, E, Cain, JE, Martelotto, LG, Martellotto, LG, Dedhar, S, Sadler, AJ, Wang, D, Watkins, DN, Hannigan, GE

EMBO Rep. 2013
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