SMO dimer binds ARRB and KIF3A

Stable Identifier
R-HSA-5632667
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endocytic vesicle membrane
ReviewStatus
5/5
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SMO dimer binds ARRB and KIF3A
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Beta-arrestin 1 and 2 (ARRB1 and 2) and the anterograde motor protein KIF3A bind to SMO and may be required for its ciliary accumulation after Hh stimulation (Kovacs et al, 2008; Barakat et al, 2013).
Literature References
PubMed ID Title Journal Year
23877428 Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

Barakat, B, Wang, D, Dedhar, S, Martelotto, LG, Watkins, DN, Martellotto, LG, Yu, L, Lo, C, Hannigan, GE, De Luca, E, Cain, JE, Vu, D, Sadler, AJ

EMBO Rep. 2013
18497258 Beta-arrestin-mediated localization of smoothened to the primary cilium

Chen, W, Liu, R, Kim, J, Wang, J, Chen, M, Whalen, EJ, Kovacs, JJ, Lefkowitz, RJ, Xiao, K

Science 2008
Participants
Input
Output
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Inferred From
Smo dimer binds Arrb and Kif3a (Mus musculus)
Authored
Rothfels, K  (2014-10-20)
Reviewed
Liu, Y C  (2014-11-09)
Created
Rothfels, K  (2014-10-28)
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