TP53 (p53) binds to the p53 response element in the intron 2 of SESN1 gene and stimulates transcription of SESN1 transcripts SESN1-1 and SESN1-3, also known as PA26 T2 and PA26 T3 (Velasco-Miguel et al. 1999). Recently, TP53 binding to SESN2 gene regulatory elements has been identified by ChIPseq (Menendez et al. 2013), and SESN2 gene expression was previously shown to be responsive to TP53 (Budanov et al. 2002). Rat ortholog of SESN3 was shown to possess p53 binding sites in the promoter region, but direct binding of TP53 to regulatory elements of human SESN3 has not been examined (Brynczka et al. 2007).
Menendez, D, Anderson, CW, Nguyen, TA, Mathew, VJ, Jothi, R, Freudenberg, JM, Resnick, MA
Gelbert, L, Laidlaw, J, Talbott, R, Seizinger, B, Buckbinder, L, Jean, P, Kley, N, Velasco-Miguel, S
Labhart, P, Brynczka, C, Merrick, BA
Feinstein, E, Gudkov, AV, Chajut, A, Kamer, I, Kalinski, H, Fishman, A, Shoshani, T, Skaliter, R, Budanov, AV, Chumakov, PM, Zelin, E, Einat, P, Faerman, A, Gorodin, S
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