TP53 binds regulatory elements of SESN1,2,3 genes

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TP53 (p53) binds to the p53 response element in the intron 2 of SESN1 gene and stimulates transcription of SESN1 transcripts SESN1-1 and SESN1-3, also known as PA26 T2 and PA26 T3 (Velasco-Miguel et al. 1999). Recently, TP53 binding to SESN2 gene regulatory elements has been identified by ChIPseq (Menendez et al. 2013), and SESN2 gene expression was previously shown to be responsive to TP53 (Budanov et al. 2002). Rat ortholog of SESN3 was shown to possess p53 binding sites in the promoter region, but direct binding of TP53 to regulatory elements of human SESN3 has not been examined (Brynczka et al. 2007).
Literature References
PubMed ID Title Journal Year
23775793 Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

Menendez, D, Anderson, CW, Nguyen, TA, Mathew, VJ, Jothi, R, Freudenberg, JM, Resnick, MA

Nucleic Acids Res. 2013
9926927 PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

Gelbert, L, Laidlaw, J, Talbott, R, Seizinger, B, Buckbinder, L, Jean, P, Kley, N, Velasco-Miguel, S

Oncogene 1999
17540029 NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation

Labhart, P, Brynczka, C, Merrick, BA

BMC Genomics 2007
12203114 Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

Feinstein, E, Gudkov, AV, Chajut, A, Kamer, I, Kalinski, H, Fishman, A, Shoshani, T, Skaliter, R, Budanov, AV, Chumakov, PM, Zelin, E, Einat, P, Faerman, A, Gorodin, S

Oncogene 2002
Cite Us!