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SRY [nucleoplasm]
Stable Identifier
R-HSA-5627706
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Sex-determining region Y protein, SRY_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of testis differentiation (Homo sapiens)
Expression of SOX9 in testis differentiation (Homo sapiens)
SRY:NR5A1:SOX9 gene [nucleoplasm] (Homo sapiens)
SRY [nucleoplasm] (Homo sapiens)
Expression of SRY in testis differentiation (Homo sapiens)
SRY [nucleoplasm] (Homo sapiens)
SOX9 binds the SOX9 gene (Homo sapiens)
SRY:NR5A1:SOX9 gene [nucleoplasm] (Homo sapiens)
SRY [nucleoplasm] (Homo sapiens)
SRY and NR5A1 (SF1) bind SOX9 gene (Homo sapiens)
SRY [nucleoplasm] (Homo sapiens)
SRY:NR5A1:SOX9 gene [nucleoplasm] (Homo sapiens)
SRY [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
Beta-catenin binds SOX proteins (Homo sapiens)
CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
SRY [nucleoplasm] (Homo sapiens)
SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
SRY [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q05066 SRY
Gene Names
SRY, TDF
Chain
chain:1-204
Reference Genes
BioGPS Gene:6736 SRY
COSMIC (genes):SRY SRY
CTD Gene:6736 SRY
dbSNP Gene:6736 SRY
ENSEMBL:ENSG00000184895 SRY
HGNC:11311 SRY
KEGG:hsa:6736 SRY
Monarch:6736 SRY
NCBI Gene:6736 SRY
OMIM:480000 SRY
UCSC:Q05066 SRY
Reference Transcript
RefSeq:NM_003140.2 SRY
Other Identifiers
11738437_at
17116761
207893_PM_at
207893_at
32864_at
4033460
4033461
4033462
4033463
4033464
4033465
6736
8177038
A_23_P85265
GE550734
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001228
GO:0003677
GO:0003700
GO:0005515
GO:0005516
GO:0005634
GO:0005654
GO:0005737
GO:0006355
GO:0007420
GO:0007548
GO:0009653
GO:0010628
GO:0016607
GO:0022414
GO:0030154
GO:0030182
GO:0030238
GO:0043226
GO:0045893
GO:0045944
GO:0048856
GO:0140110
GO:0140297
GO:2000020
HMNXSV003020293
ILMN_1748182
L10102_rna1_at
PH_hs_0000265
TC0Y000121.hg
g4507224_3p_at
Participates
as an output of
Expression of SRY in testis differentiation (Homo sapiens)
as an input of
SRY and NR5A1 (SF1) bind SOX9 gene (Homo sapiens)
as a component of
SRY:NR5A1:SOX9 gene [nucleoplasm] (Homo sapiens)
as a member of
SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
Inferred To
Sox14 [nucleoplasm]
(Drosophila melanogaster)
SRY [nucleoplasm]
(Canis familiaris)
SRY [nucleoplasm]
(Sus scrofa)
sox17b.3 [nucleoplasm]
(Xenopus tropicalis)
D [nucleoplasm]
(Drosophila melanogaster)
sox15 [nucleoplasm]
(Xenopus tropicalis)
sox-3 [nucleoplasm]
(Caenorhabditis elegans)
sem-2 [nucleoplasm]
(Caenorhabditis elegans)
sox21 [nucleoplasm]
(Xenopus tropicalis)
Homologues of SRY [nucleoplasm]
(Caenorhabditis elegans)
Homologues of SRY [nucleoplasm]
(Danio rerio)
Homologues of SRY [nucleoplasm]
(Drosophila melanogaster)
Homologues of SRY [nucleoplasm]
(Xenopus tropicalis)
Sox21a [nucleoplasm]
(Drosophila melanogaster)
sox21b [nucleoplasm]
(Danio rerio)
sox19a [nucleoplasm]
(Danio rerio)
sox-4 [nucleoplasm]
(Caenorhabditis elegans)
sox32 [nucleoplasm]
(Danio rerio)
SoxN [nucleoplasm]
(Drosophila melanogaster)
sox1b [nucleoplasm]
(Danio rerio)
sox-2 [nucleoplasm]
(Caenorhabditis elegans)
LOC116407953 [nucleoplasm]
(Xenopus tropicalis)
sox1a [nucleoplasm]
(Danio rerio)
sox3 [nucleoplasm]
(Danio rerio)
sox3 [nucleoplasm]
(Xenopus tropicalis)
Sox21b [nucleoplasm]
(Drosophila melanogaster)
SOX21 [nucleoplasm]
(Gallus gallus)
sox19b [nucleoplasm]
(Danio rerio)
Sox15 [nucleoplasm]
(Drosophila melanogaster)
sox17b.1 [nucleoplasm]
(Xenopus tropicalis)
sox21a [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_003131.1
ENSEMBL
ENST00000383070
,
ENSP00000372547
OpenTargets
ENSG00000184895
HPA
ENSG00000184895-SRY
PRO
Q05066
Pharos - Targets
Q05066
Orphanet
SRY
HMDB Protein
HMDBP08587
PDB
1HRZ
,
1HRY
,
1J47
,
1J46
,
2GZK
,
6EDB
,
7YHO
,
7YHQ
,
7YHP
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15599 NHRF2
0.733
9
UniProt:P84022 SMAD3
20
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
0.499
3
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