GOPC promotes translocation of CFTR to lysosomes

Stable Identifier
R-HSA-5627275
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi-associated vesicle membrane, lysosomal membrane
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GOPC promotes translocation of CFTR to lysosomes
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Binding of GOPC (also known as CAL, PIST or FIG) to CFTR (cystic fibrosis transmembrane conductance regulator) promotes translocation of GOPC:CFTR complex to lysosomes, which is followed by lysosomal degradation of CFTR (Cheng et al. 2005).

Literature References
PubMed ID Title Journal Year
15546864 Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10

Cheng, J, Wang, H, Guggino, WB

J. Biol. Chem. 2005
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
GOPC:CFTR [Golgi-associated vesicle membrane] (Homo sapiens)
Active Unit
GOPC dimer [Golgi-associated vesicle membrane]
Orthologous Events
GOPC promotes translocation of CFTR to lysosomes (Caenorhabditis elegans)
GOPC promotes translocation of CFTR to lysosomes (Canis familiaris)
GOPC promotes translocation of CFTR to lysosomes (Danio rerio)
GOPC promotes translocation of CFTR to lysosomes (Gallus gallus)
GOPC promotes translocation of CFTR to lysosomes (Mus musculus)
GOPC promotes translocation of CFTR to lysosomes (Sus scrofa)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2014-10-17)
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