GOPC promotes translocation of CFTR to lysosomes

Stable Identifier
R-HSA-5627275
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi-associated vesicle membrane, lysosomal membrane
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GOPC promotes translocation of CFTR to lysosomes
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Binding of GOPC (also known as CAL, PIST or FIG) to CFTR (cystic fibrosis transmembrane conductance regulator) promotes translocation of GOPC:CFTR complex to lysosomes, which is followed by lysosomal degradation of CFTR (Cheng et al. 2005).

Literature References
PubMed ID Title Journal Year
15546864 Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10

Cheng, J, Wang, H, Guggino, WB

J. Biol. Chem. 2005
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Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2014-10-17)