Reactome | RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane

RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane

Stable Identifier

R-HSA-5627071

Type

Reaction

Species

Homo sapiens

Compartment

Golgi-associated vesicle membrane, plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

While binding of GOPC (also known as CAL, PIST or FIG) to CFTR (cystic fibrosis transmembrane conductance regulator) promotes lysosomal degradation of CFTR, binding of active RHOQ to GOPC:CFTR complex redirects CFTR to the plasma membrane and prevents its degradation (Cheng et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15546864	Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10 Cheng, J, Wang, H, Guggino, WB	J. Biol. Chem.	2005