While binding of GOPC (also known as CAL, PIST or FIG) to CFTR (cystic fibrosis transmembrane conductance regulator) promotes lysosomal degradation of CFTR, binding of active RHOQ to GOPC:CFTR complex redirects CFTR to the plasma membrane and prevents its degradation (Cheng et al. 2005).
Cheng, J, Guggino, WB, Wang, H
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