RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane

Stable Identifier
R-HSA-5627071
Type
Reaction
Species
Homo sapiens
Compartment
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While binding of GOPC (also known as CAL, PIST or FIG) to CFTR (cystic fibrosis transmembrane conductance regulator) promotes lysosomal degradation of CFTR, binding of active RHOQ to GOPC:CFTR complex redirects CFTR to the plasma membrane and prevents its degradation (Cheng et al. 2005).

Literature References
PubMed ID Title Journal Year
15546864 Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10

Cheng, J, Wang, H, Guggino, WB

J. Biol. Chem. 2005
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