Reactome | TNF-α:TNFR1 binds NSMAF

TNF-α:TNFR1 binds NSMAF

Stable Identifier

R-HSA-5626988

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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TNF-α-induced signaling by TNFR1 promotes the activation of sphingomyelin phosphodiesterase (sphingomyelinase or SMASE) signaling pathways. SMASE is a family of an agonist-activated effector enzymes that hydrolyze phospholipids on the membrane compartments to produce ceramide, a lipid-signaling molecule.

Factor associated with neutral sphingomyelinase activation (FAN or NSMAF) is an adaptor protein that constitutively binds to the neutral SMASE activation domain (NSD) of TNFR1 (Adam-Klages S et al. 1996). NSMAF (FAN) is thought to directly link TNFR1 to the activation of neutral sphingomyelinase (N-SMASE) such as sphingomyelin phosphodiesterase 2 or 3 (SMPD2, SMPD3).

Literature References

PubMed ID	Title	Journal	Year
11435466	Involvement of FAN in TNF-induced apoptosis Ségui, B, Cuvillier, O, Adam-Klages, S, Garcia, V, Malagarie-Cazenave, S, Lévêque, S, Caspar-Bauguil, S, Coudert, J, Salvayre, R, Krönke, M, Levade, T	J. Clin. Invest.	2001
8808629	FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase Adam-Klages, S, Adam, D, Wiegmann, K, Struve, S, Kolanus, W, Schneider-Mergener, J, Krönke, M	Cell	1996
8663014	A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway Adam, D, Wiegmann, K, Adam-Klages, S, Ruff, A, Krönke, M	J. Biol. Chem.	1996