TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3

Stable Identifier
R-HSA-5626981
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Sphingolipid signaling is initiated by neutral sphingomyelinase (neutral SMASE), a family of agonist-activated effector enzymes.

Literature References
PubMed ID Title Journal Year
20080539 The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase

Philipp, S, Puchert, M, Adam-Klages, S, Tchikov, V, Winoto-Morbach, S, Mathieu, S, Deerberg, A, Kolker, L, Marchesini, N, Kabelitz, D, Hannun, YA, Schütze, S, Adam, D

Proc. Natl. Acad. Sci. U.S.A. 2010
12391233 Interaction with factor associated with neutral sphingomyelinase activation, a WD motif-containing protein, identifies receptor for activated C-kinase 1 as a novel component of the signaling pathways of the p55 TNF receptor

Tcherkasowa, AE, Adam-Klages, S, Kruse, ML, Wiegmann, K, Mathieu, S, Kolanus, W, Krönke, M, Adam, D

J. Immunol. 2002
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