C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole

Stable Identifier
Reaction [binding]
Homo sapiens
Centrosome:C2CD3 binds distal appendage proteins
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C2CD3 and the centrosome component OFD1 are required for the recruitment of distal appendage proteins CEP164, CEP83/CCDC41, CEP89, FBF1 and SCLT1 to the mother centriole (Ye et al, 2014; Tang et al, 2013; Singla et al, 2010). Distal appendage proteins are believed to form part of the transition fibres that anchor the basal bodies to the actin rich cortex at the base of the emerging cilium, and are also required for the recruitment and binding of ciliary vesicles and intraflagellar transport (IFT) complexes (Tanos et al, 2013; Wei et al, 2013; Joo et al, 2010; Schmidt et al, 2012; Sillibourne et al, 2013; Ye et al, 2014; reviewed in Winey and O'Toole, 2014).

Literature References
PubMed ID Title Journal Year
24469809 C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals

Zeng, H, Ning, G, Liu, A, Reiter, JF, Ye, X

Proc. Natl. Acad. Sci. U.S.A. 2014
23253480 Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis

Hub, B, Neuner, A, Zentgraf, H, Kuhns, S, Schmidt, KN, Pereira, G

J. Cell Biol. 2012
24089205 Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites

Zhong, Q, Zhu, M, Franco, B, Lin, MG, Tang, Z, Stowe, TR, Stearns, T, Chen, S

Nature 2013
23348840 Centriole distal appendages promote membrane docking, leading to cilia initiation

Tanos, BE, Soni, R, Wang, WJ, Tsou, MF, Macaluso, FP, Asara, JM, Yang, HJ

Genes Dev. 2013
23530209 CCDC41 is required for ciliary vesicle docking to the mother centriole

Kim, J, Kim, CH, Park, WY, Kim, CG, Gleeson, JG, Kweon, HS, Kim, MJ, Lee, SH, Lee, MS, Moon, HY, Joo, K

Proc. Natl. Acad. Sci. U.S.A. 2013
25047611 Centriole structure

O'Toole, E, Winey, M

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2014
20230748 Ofd1, a human disease gene, regulates the length and distal structure of centrioles

Singla, V, Romaguera-Ros, M, GarcĂ­a-Verdugo, JM, Reiter, JF

Dev. Cell 2010
23789104 Primary ciliogenesis requires the distal appendage component Cep123

Tran, P, Hurbain, I, Grand-Perret, T, Goud, B, Bornens, M, Sillibourne, JE

Biol Open 2013
24231678 Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes

Torres, VE, Hu, Z, Ling, K, Wei, Q, Hu, J, Zhang, Q, Li, Y, Zhang, Y, Harris, PC, Xu, Q

Nat Commun 2013
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